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Adolescent Substance Use in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (ADHD) (MTA) as a Function of Childhood ADHD, Random Assignment to Childhood Treatments, and Subsequent Medication
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Molina, Brooke S. G.; Hinshaw, Stephen P.; Arnold, L. Eugene; Swanson, James M.; Pelham, William E.; Hechtman, Lily; Hoza, Betsy; Epstein, Jeffery N.; Wigal, Timothy; Abikoff, Howard B.; Greenhill, Laurence L.; Jensen, Peter S.; Wells, Karen C.; Vitiello, Benedetto; Gibbons, Robert D.; Howard, Andrea; Houck, Patricia R.; Hur, Kwan; Lu, Bo; Marcus, Sue – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: To determine long-term effects on substance use and substance use disorder (SUD), up to 8 years after childhood enrollment, of the randomly assigned 14-month treatments in the multisite Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (MTA; n = 436); to test whether medication at follow-up, cumulative…
Descriptors: Prevention, Substance Abuse, Attention Deficit Hyperactivity Disorder, Adolescents
Psychotropic Medication Treatment of Adolescents: Results from the National Comorbidity Survey-Adolescent Supplement
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Olfson, Mark; He, Jian-ping; Merikangas, Kathleen Ries – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: To examine the 12-month prevalence of psychotropic medication use among adolescents, and the match between mental disorder diagnoses and past-year antidepressant and stimulant use. Method: Data are from the National Comorbidity Survey--Adolescent Supplement (2002-2004), a nationally representative survey of 10,123 adolescents aged 13 to…
Descriptors: Attention Deficit Hyperactivity Disorder, Adolescents, Anxiety Disorders, Drug Therapy
Characterization of Adolescent Prescription Drug Abuse and Misuse Using the Researched Abuse Diversion and Addiction-Related Surveillance (RADARS[R]) System
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Zosel, Amy; Bartelson, Becki Bucher; Bailey, Elise; Lowenstein, Steven; Dart, Rick – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: To describe the characteristics and health effects of adolescent (age 13-19 years) prescription drug abuse and misuse using the Researched Abuse Diversion and Addiction-Related Surveillance (RADARS[R])) System. Method: Secondary analysis of data collected from RADARS System participating poison centers was performed. Data for all…
Descriptors: Adolescents, Drug Abuse, Attention Deficit Disorders, Narcotics
A Controlled Trial of Extended-Release Guanfacine and Psychostimulants for Attention-Deficit/Hyperactivity Disorder
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Wilens, Timothy E.; Bukstein, Oscar; Brams, Matthew; Cutler, Andrew J.; Childress, Ann; Rugino, Thomas; Lyne, Andrew; Grannis, Kara; Youcha, Sharon – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: To examine efficacy, tolerability, and safety of guanfacine extended release (GXR; less than or equal to 4 mg/d) adjunctive to a long-acting psychostimulant for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents 6 to 17 years of age with suboptimal, but partial, response to psychostimulant…
Descriptors: Attention Deficit Hyperactivity Disorder, Safety, Rating Scales, Severity (of Disability)
Stimulants and Cardiovascular Events in Youth with Attention-Deficit/Hyperactivity Disorder
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Olfson, Mark; Huang, Cecilia; Gerhard, Tobias; Winterstein, Almut G.; Crystal, Stephen; Allison, Paul D.; Marcus, Steven C. – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: This study examined associations between stimulant use and risk of cardiovascular events and symptoms in youth with attention-deficit/hyperactivity disorder and compared the risks associated with methylphenidate and amphetamines. Method: Claims were reviewed of privately insured young people 6 to 21 years old without known…
Descriptors: Attention Deficit Hyperactivity Disorder, Stimulants, Cohort Analysis, Risk
Cardiovascular Risk of Stimulant Treatment in Pediatric Attention-Deficit/Hyperactivity Disorder: Update and Clinical Recommendations
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Hammerness, Paul G.; Perrin, James M.; Shelley-Abrahamson, Rachel; Wilens, Timothy E. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: This review provides an update on the cardiovascular impact of therapeutic stimulant-class medication for children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Method: Relevant clinical literature was ascertained using PubMed searches limited to human studies and the English language as of May 2011. Current…
Descriptors: Attention Deficit Hyperactivity Disorder, Metabolism, Stimulants, Adolescents
Does Childhood Attention-Deficit/Hyperactivity Disorder Predict Risk-Taking and Medical Illnesses in Adulthood?
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Ramos Olazagasti, Maria A.; Klein, Rachel G.; Mannuzza, Salvatore; Belsky, Erica Roizen; Hutchison, Jesse A.; Lashua-Shriftman, Erin C.; Castellanos, F. Xavier – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: To test whether children with attention-deficit/hyperactivity disorder (ADHD), free of conduct disorder (CD) in childhood (mean = 8 years), have elevated risk-taking, accidents, and medical illnesses in adulthood (mean = 41 years); whether development of CD influences risk-taking during adulthood; and whether exposure to…
Descriptors: Accidents, Attention Deficit Hyperactivity Disorder, Children, Diseases
Abnormal Amygdalar Activation and Connectivity in Adolescents with Attention-Deficit/Hyperactivity Disorder
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Posner, Jonathan; Nagel, Bonnie J.; Maia, Tiago V.; Mechling, Anna; Oh, Milim; Wang, Zhishun; Peterson, Bradley S. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: Emotional reactivity is one of the most disabling symptoms associated with attention-deficit/hyperactivity disorder (ADHD). We aimed to identify neural substrates associated with emotional reactivity and to assess the effects of stimulants on those substrates. Method: We used functional magnetic resonance imaging (fMRI) to assess neural…
Descriptors: Attention Deficit Hyperactivity Disorder, Stimulants, Adolescents, Emotional Response
Pharmacogenetic Predictors of Methylphenidate Dose-Response in Attention-Deficit/Hyperactivity Disorder
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Froehlich, Tanya E.; Epstein, Jeffery N.; Nick, Todd G.; Melguizo Castro, Maria S.; Stein, Mark A.; Brinkman, William B.; Graham, Amanda J.; Langberg, Joshua M.; Kahn, Robert S. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: Because of significant individual variability in attention-deficit/hyperactivity disorder (ADHD) medication response, there is increasing interest in identifying genetic predictors of treatment effects. This study examined the role of four catecholamine-related candidate genes in moderating methylphenidate (MPH) dose-response. Method:…
Descriptors: Attention Deficit Hyperactivity Disorder, Rating Scales, Drug Therapy, Identification
Clinical, Demographic, and Familial Correlates of Bipolar Spectrum Disorders among Offspring of Parents with Bipolar Disorder
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Goldstein, Benjamin I.; Shamseddeen, Wael; Axelson, David A.; Kalas, Cathy; Monk, Kelly; Brent, David A.; Kupfer, David J.; Birmaher, Boris – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Despite increased risk, most offspring of parents with bipolar disorder (BP) do not manifest BP. The identification of risk factors for BP among offspring could improve preventive and treatment strategies. We examined this topic in the Pittsburgh Bipolar Offspring Study (BIOS). Method: Subjects included 388 offspring, ages 7-17 years,…
Descriptors: Mental Disorders, Risk, Children, Adolescents
Review of ADHD Pharmacotherapies: Advantages, Disadvantages, and Clinical Pearls
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Daughton, Joan M.; Kratochvil, Christopher J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
The advantages, disadvantages, as well as helpful hints on when to use several drug therapies against attention deficit hyperactivity disorder are discussed. The drugs discussed are methylphenidate, atomoxetine, clonidine, and bupropion.
Descriptors: Attention Deficit Hyperactivity Disorder, Drug Therapy, Outcomes of Treatment, Pharmacology
Stimulant Adherence and Academic Performance in Urban Youth with Attention-Deficit/Hyperactivity Disorder
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Marcus, Steven C.; Durkin, Michael – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: This analysis assessed whether stimulant adherence was associated with improvement in academic grade point average (GPA) among children diagnosed with and treated for attention-deficit/hyperactivity disorder (ADHD). Method: Medicaid claims were merged with academic records from Philadelphia public schools of Medicaid-eligible children…
Descriptors: Attention Deficit Hyperactivity Disorder, Academic Records, Middle School Students, Stimulants
Effects of Lisdexamfetamine Dimesylate Treatment for ADHD on Growth
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Faraone, Stephen V.; Spencer, Thomas J.; Kollins, Scott H.; Glatt, Stephen J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To complete an exploratory uncontrolled study of the effects of lisdexamfetamine dimesylate (LDX) on growth of children treated for attention-deficit/hyperactivity disorder (ADHD). Method: Height, weight, and body mass index (BMI) from 281 children ages 6 to 13 years from longitudinal assessments up to 15 months were compared to norms…
Descriptors: Attention Deficit Hyperactivity Disorder, Disease Control, Body Composition, Diseases
Characteristics of Placebo Responders in Pediatric Clinical Trials of Attention-Deficit/Hyperactivity Disorder
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Newcorn, Jeffrey H.; Sutton, Virginia K.; Zhang, Shuyu; Wilens, Timothy; Kratochvil, Christopher; Emslie, Graham J.; D'Souza, Deborah N.; Schuh, Leslie M.; Allen, Albert J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Objective: Understanding placebo response is a prerequisite to improving clinical trial methodology. Data from placebo-controlled trials of atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) were analyzed to identify demographic and clinical characteristics that might predict placebo…
Descriptors: Attention Deficit Hyperactivity Disorder, Stimulants, Rating Scales, Patients
Effects of Stimulants on Height and Weight: A Review of the Literature
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Faraone, Stephen V.; Biederman, Joseph; Morley, Christopher P.; Spencer, Thomas J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2008
The article reviews existing literature on the effects of stimulant medications on the growth of children with attention-deficit/hyperactivity disorder. It concludes that treatment with stimulants in childhood results in moderate growth deficit in height and weight.
Descriptors: Stimulants, Hyperactivity, Attention Deficit Disorders, Body Weight
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