Sleep is crucial for memory consolidation, underpinning effective learning. Targeted memory reactivation (TMR) can strengthen neural representations by re-engaging learning circuits during sleep. However, TMR protocols overlook individual differences in learning capacity and memory trace strength, limiting efficacy for difficult-to-recall…

Evidence implicating theta rhythms in declarative memory encoding and retrieval, together with the notion that both retrieval and consolidation involve memory reinstatement or replay, suggests that post-learning theta rhythm modulation can promote early consolidation of newly formed memories. Building on earlier work employing theta neurofeedback,…

Background: Most adults with Down syndrome develop Alzheimer's disease (AD) pathology in their 30s, yet research into cognitive health programmes for this group remains limited. Method: A mixed-methods feasibility randomised control trial (RCT) evaluated an adapted, manualised group-based cognitive stimulation therapy (CST) programme for adults…

This research comprises two studies investigating the impact of mood and cognitive stimulation on creativity, with a focus on the role of task type. The first study focused on idea generation, whereas the second explored slogan generation, revealing differing outcomes for distinct tasks. Positive and negative moods were induced through memory…

Applying 10 Hz ([alpha]-rate) sensory stimulation, not 5 Hz ([theta]-rate), prior to introducing novel speech-print pairs can reset the phase of [theta] oscillations and enhance associative learning. This rapid gain indicates coordinated mechanisms to regulate attentional/cognitive resources ([alpha] oscillations) and facilitate memory storage…

Linguistic categories can impact visual perception. For instance, learning that two objects have different names can enhance their discriminability. Previous studies have identified a typical pattern of categorical perception, characterized by faster discrimination of stimuli from different categories, a neural mismatch response during early…

The primary motor cortex (M1) is crucial for motor skill learning. We examined its role in interleaved practice, which enhances retention (vs. repetitive practice) through M1-dependent consolidation. We hypothesized that cathodal transcranial direct current stimulation (ctDCS) to M1 would disrupt retention. We found that ctDCS reduced retention…

Finding interventions which can address the decline of cognitive function as people get older is of great importance to policy-makers, especially in post-industrial societies with rapidly ageing populations. We examine the impact of several different types of mentally stimulating activities on cognitive function in a sample of community-dwelling…

Fear generalization is one of the main symptoms of posttraumatic stress disorder. In rodents, the anterior cingulate cortex (ACC) and the hippocampus (HPC) control the expression of contextual fear memory generalization. Consistently, ACC projections to the ventral HPC contribute to contextual fear generalization. However, the roles of ACC…

Neocortical sleep spindles have been shown to occur more frequently following a memory task, suggesting that a method to increase spindle activity could improve memory processing. Stimulation of the neocortex can elicit a slow oscillation (SO) and a spindle, but the feasibility of this method to boost SO and spindles over time has not been tested.…

The ability to remember future actions (prospective memory) is an important determinant of daily functioning in older adults. While social wellbeing is associated with better cognitive function generally, it is unknown how social wellbeing affects, and is affected by, prospective memory. Using a two-wave longitudinal design, we investigated the…

Beta-adrenergic receptors ([beta]-ARs) prime hippocampal synapses to stabilize long-term potentiation (LTP). This "metaplasticity" can persist for 1-2 h after pharmacologic activation of [beta]-ARs. It requires activation of PKA (cAMP-dependent protein kinase) during [beta]-AR priming. A-kinase anchoring proteins (AKAPs) tether PKA to…

This qualitative research explored why older people do not participate in formal and nonformal education. This study focused on older adults who have not participated in formal or nonformal education since their retirement. Recent studies have shown that participation in formal and nonformal educational activities is an effective way to maintain…

Functional neuroimaging studies suggest a role for the left angular gyrus (AG) in processes related to memory recognition. However, results of neuropsychological and transcranial magnetic stimulation (TMS) studies have been inconclusive regarding the specific contribution of the AG in recollection, familiarity, and the subjective experience of…

The formation of mate recognition memory in mice is associated with neural changes at the reciprocal dendrodendritic synapses between glutamatergic mitral cell (MC) projection neurons and GABAergic granule cell (GC) interneurons in the accessory olfactory bulb (AOB). Although noradrenaline (NA) plays a critical role in the formation of the memory,…