The purpose of this study was to determine whether there is a relationship between mindfulness, resilience, and perceived social support with emotional well-being in santri during the COVID-19 pandemic. This study is quantitative. Data collection tools in this study used a mindfulness scale, resilience scale, perceived social support scale and emotional well-being scale. Subjects in this study amounted to 363 of the total population of 965 santri through the purposive accidental sampling technique. The method used in this study is a quantitative method with Structural Equation Modeling (SEM) techniques. The results of this study show the R Square value of 0,166 which means that the variables of mindfulness, resilience, and perceived social support have an effect of 16,6% on emotional well-being, while 83.4% is influenced by other variables. So that the proposed hypothesis is accepted, meaning that the higher the mindfulness, resilience, and perceived social support, the higher the perceived emotional well-being.