The authors compared student perceptions and performance in an Anatomy and Physiology II course during the transition from face-to-face (F2F) pre-COVID-19 pandemic learning to online (OL) pandemic learning. Students and instructors completed the Student Assessment of Their Learning Gains (SALG) survey; perceptions were positive regarding both F2F and OL delivery modes. Student performance was higher on both F2F and OL quizzes in 2020 compared to the same quizzes in F2F 2019; no differences were observed in exam grades in 2019 and 2020. No unsatisfactory grades were noted. The sudden shift to OL learning had no negative effects and, in some cases, improved student performance.