This study examines how Asian American and Native American Pacific Islander-Serving Institutions (AANAPISI) serve Asian American, Native Hawaiian, and Pacific Islander (AA&NHPI) students. Through a two-site case study of a community college on the west coast and a regional comprehensive university on the east coast, this study details the processes that are undertaken to serve and enhance the educational experiences of AA&NHPI students by building their capacities. Findings suggests that federally-funded AANAPISIs design and implement their programs in a manner that reflects the lived experiences and realities of AA&NHPI students through academic coursework, co-curricular programming, and research opportunities, in an intentional and strategic multilayered process, which resembles a developmental nested design focused on five thematic domains. Implications for policy, practice, and research are also offered to advance the work of AANAPISIs.