The modeling of rates of biochemical reactions--fluxes--in metabolic networks is widely used for both basic biological research and biotechnological applications. A number of different modeling methods have been developed to estimate and predict fluxes, including kinetic and constraint-based (Metabolic Flux Analysis and flux balance analysis)…

Biological systems exhibit strong dynamic variations; for example, a system may have a tendency towards either a steady state, periodic behaviour or chaotic oscillations. These findings, explained by dynamic systems theory, have allowed researchers to formally relate a wide variety of systems, such as the theory of rumour propagation, glucose…