Instructional strategies are essential to reform initiatives in science, technology, engineering, and mathematics (STEM) education. The problem was higher education instructors in STEM disciplines continue to use siloed and teacher-centered strategies in courses even though integrated and student-centered approaches are more effective in engaging students. The purpose of the basic qualitative study was to explore perceptions from college-level instructors on how leaders can address the challenges and supports needed for student-centered and integrative approaches to STEM in higher education. A lack of perspectives on college instructors implementing integrated and student-centered strategies has revealed a gap in the literature. Lewin's (1947) change theory and Burns' (1978) transformational leadership theory were used as guides for the theoretical framework. Key research questions explored higher education instructors' perspectives and experiences with implementing integrated and student-centered practices. A basic qualitative research design was used to gather the perspectives of college instructors with a sample size of 15 participants. Selection criterion was snowball sampling to include instructors who teach one or more of the STEM disciplines. An online questionnaire and course syllabi were the instruments for data collection. Data analysis involved using document analysis and an inductive thematic analysis process. Findings comprised of instructors' positive views and challenges of student-centered and integrative methods. Training and resources were identified as supports needed by leaders to implement STEM education pedagogy. Recommendations include defining a mission to drive organizational change and providing training for instructors. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]