One of the essential skills that pharmacy students should develop is the ability to evaluate randomized controlled trials (RCTs) to assess the clinical efficacy and safety of pharmaceuticals. This study aimed to enhance the RCT evaluation skills of fifth-year pharmacy students. It employed the CASP checklist application to assess clinical studies on new drugs. The teaching approach combined theory and hands-on CASP checklist application for RCT assessment, comprising four stages: 1) introducing principles and providing example RCT evaluations, 2) assigning individual students the RCT analysis tasks, 3) instructor feedback, and 4) collaborative group assignments for new drug evaluations using CASP. Student performance was evaluated with a rubric. The study identified notable improvements in students' RCT evaluating skills, with an initial average score of 71.11 ± 5.57%. While room for improvement in understanding, summarizing, and clear expression of opinions exist, incorporating instructors' feedback led to a significant improvement (96.11 ± 8.32%) in individual assignments. Group scores for new drug evaluations averaged over 80% (86.61 ± 6.93%). These findings demonstrate that students developed RCT evaluation skills and enhanced understanding, critical thinking, and problem-solving abilities. In conclusion, this teaching approach effectively improved students' RCT evaluation skills through the CASP checklist application, fostering their proficiency and understanding. This equips students with essential tools for future pharmacy practice and professional development. [For the complete proceedings, see ED672804.]