The purpose of this study was to test the effectiveness of a course taught with worksheets on the subject of blood circulation. The study was conducted with students aged 12-13 in a single class at a public middle school. This worksheet has seven questions in total. At the end of the lesson, the students' opinions about the lesson were obtained through an open-ended interview form. The data obtained from these open-ended interviews were analyzed via content analysis. According to the analysis results, the students learned the subject meaningfully. Students learned better thanks to teaching with worksheets. Therefore, it has been stated that such studies, as in this study, can be useful in terms of science teaching and that it would be appropriate to use them in teaching other subjects as well.