Collaborative inquiry is an instructional approach that encourages student groups to engage in scientific inquiry processes, thereby enhancing their critical thinking and exploratory skills. The effective classroom implementation of this method requires ensuring student engagement in each inquiry stage, where technological tools and activity strategies play a crucial role in supporting their inquiry processes. However, the technological tools and activity strategies that contribute to designing classroom activities and fostering students' engagement in collaborative inquiry remain unclear. This systematic review analyzed 58 empirical studies on technology-enhanced collaborative inquiry in K-12 classrooms. We examined the characteristics of these studies, the technological tools and activity strategies employed, and their reported outcomes and effects on student learning. The results indicate that most classroom practices featured diverse technological tools and activity strategies to support students in collaboratively performing stages of inquiry tasks. The findings highlight the need for further research into effectively integrating technological tools with activity strategies to provide adaptive support for specific inquiry processes, such as hypothesis generation and scientific argumentation. Our synthesis of previous outcome measurements revealed the positive impacts of technology-enhanced collaborative inquiry on students' content knowledge, overall inquiry process, and scientific skills like argumentation. The implications of these findings are discussed for both researchers and practitioners, emphasizing the necessity of integrating appropriate technological tools and activity strategies to effectively facilitate collaborative inquiry in K-12 classrooms.