Opportunities to respond (OTR) offer a useful approach to actively engage all students, including those with emotional and behavioral disorders, by enhancing their learning experiences and effectively reducing student problematic behavior due to lack of academic engagement. In this article, we discuss common challenges faced by teachers in delivering OTR during instruction, including achieving adequate OTR delivery rates, delivering OTR with essential components, embedding varied types of OTR, and balancing student engagement strategies. To assist teachers in overcoming the challenges, we propose solutions, including intentional planning, goal setting with performance feedback, data-driven coaching support, and managing instruction for higher-order thinking. We also present cases and illustrate how teachers can use the proposed solutions to overcome the challenges associated with OTR delivery.