Digital transformation in African higher education institutions is a complex and multifaceted process that requires deliberate investment, meticulous planning, and collaboration. This article analyses African higher education institutions' challenges in incorporating diversity, equity, and inclusion into their digital transformation efforts. These challenges are grouped into three categories: digital infrastructure; diversity, equity, and inclusion; and policy and framework. The research highlights the hurdles involved in this process. The research underscores the challenges of African higher education institutions in integrating digital transformation into digital infrastructure. Digital infrastructure and leadership are critical in integrating diversity, equity, and inclusion to achieve digital transformation. Digital technologies can provide accessible, high-quality education that contributes to social development and benefits all African students and staff. This approach optimises the positive impact of digital technologies by ensuring that the benefits are equitably shared throughout the continent and improving learning outcomes, accessibility, and the development and competitiveness of Africa's institutions globally.