Notes that neurobehavioral problems from exposure to lead and other toxins can be observed at doses far below those that cause more obvious signs of exposure. Calls for refining tests of cognitive and developmental skills in exposed children, identifying additional contaminants and mechanisms for behavioral effects, and improving dose- repose…

The Portland Neurotoxicity Scale (PNS) is a brief patient-based survey of neurotoxicity complaints commonly encountered with the use of antiepileptic drugs (AEDs). The authors present data on the validity of this scale, particularly when used in longitudinal studies. Participants included 55 healthy controls, 23 epilepsy patient controls, and 86…

To provide graduate students in pharmacology/toxicology exposure to, and cross-training in, a variety of relevant laboratory skills, the Duquesne University School of Pharmacy developed a "methods" course as part of the core curriculum. Because some of the participating departmental faculty are neuroscientists, this course often applied…

The undergraduate chemistry club of the Southwest Minnesota State University offers assistance in lead-testing through the anodic stripping voltammetry (ASV) technique to elementary and secondary schools. Emphasis is given to this community service activity, which has increased club membership, and promoted discussion of water quality problems in…

Discusses the growing awareness of potential toxicological effects of synthetic organic chemicals contaminating groundwater. Problems concerning pesticides, chlorination, epidemiologic studies, cancer, nephrotoxicity, and considerations of risk are addressed. Additional research in this area is advocated. (DH)

Discusses the nature of toxic substances, examining pesticides and herbicides, heavy metals, industrial chemicals, and household substances. Includes a list of major toxic substances (indicating what they are, where they are found, and health concerns) and a student activity on how pesticides enter the food chain. (JN)

Examined methodological issues related to the detection and evaluation of behavioral toxicity in infants and children, focusing on the selection of appropriate variables and strategies to control for confounding, sampling strategies and the problem of "overcontrol" for confounding; and the evaluation of dose-response relations and…

Discusses environmental hazards, the problems of misinformation and contradictory information, and the problems for children in sorting out fact from hearsay. Includes tips for protecting children from environmental hazards and describes a program at the University of Washington that develops curriculum materials and other teacher resources. (PVD)

Malathion is an organophosphorus insecticide, which is often sprayed to control mosquitoes. When applied to aquatic habitats, malathion can also influence the embryogenesis of non-target organisms such as frogs and fish. We modified the frog embryo teratogen assay in "Xenopus" (FETAX), a standard toxicological assay, into an investigative…

Developmental models currently used by child behavioral toxicologists and teratologists are inadequate to address current issues in these fields. Both child behavioral teratology and toxicology scientifically study the impact of exposure to toxic agents on behavior development: teratology focuses on prenatal exposure and postnatal behavior…

This curriculum consists of a one-week course of study designed to introduce K-3 students to (or increase their awareness of) toxic substances commonly found in the home. It includes an introduction/conceptual framework and four learning activities for four concept areas (and an optional word puzzle). Each activity includes a statement of purpose,…

Discusses legislation aimed at hazardous waste issues which are implemented by the Environmental Protection Agency and state governments. Particular attention is given to Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). A case study of an abandoned acres superfund site is included with two related student…

A 2-week unit on toxic chemical waste disposal is used in a physical science course for nonscience majors. Descriptions of the unit, supplementary student activities, and student library project are provided. Also provided are selected student responses to a five-question survey on the unit. (JN)

Scientists are designing computer models of biological systems, and of compounds with complex molecules, that can be used to get answers once obtainable only by sacrificing laboratory animals. Although most programs are still under development, some are in use by industrial/pharmaceutical companies. The programs and experiments they simulate are…

Discusses the relative danger from toxicity of some typical chemicals. Notes that some materials in solutions have low toxicity, but in dust form have high toxicity. Suggests that more chemical compounds should be treated as the dangerous compounds they are. Lists common compounds found in the lab. (MVL)