The present research aimed to explore the role of media consumption, governmental distrust, and psychological vulnerability in predicting the practical well-being of university students and healthcare professionals during COVID-19. Two correlational studies were conducted. Study 1 was conducted with 411 university students (206 Women; 205 men), and it was conducted during the first lockdown in Pakistan. Study 2 was conducted during the thigh-intensity phase he COVID-19, and the sample comprised 375 healthcare professionals (198 women; 177 men). Both studies showed that higher levels of media consumption, governmental distrust, and psychological vulnerability were associated with lower levels of well-being. Our path models in both studies (with students and healthcare professionals) indicate that during the pandemic, participants' level of media consumption, trust in the government, and their personal vulnerability were negatively associated with their affective well-being. These findings have implications for individuals' affective well-being during healthcare crises such as the COVID-19 pandemic.