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Direct linkKuny, Ana V.; Althoff, Robert R.; Copeland, William; Bartels, Meike; Van Beijsterveldt, C. E. M.; Baer, Julie; Hudziak, James J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: Although oppositional defiant disorder (ODD) is usually considered the mildest of the disruptive behavior disorders, it is a key factor in predicting young adult anxiety and depression and is distinguishable from normal childhood behavior. In an effort to understand possible subsets of oppositional defiant behavior (ODB) that may…
Descriptors: Behavior Disorders, Mothers, Twins, Children
Kan, Kees-Jan; Dolan, Conor V.; Nivard, Michel G.; Middeldorp, Christel M.; van Beijsterveldt, Catharina E. M.; Willemsen, Gonneke; Boomsma, Dorret I. – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: To review findings on attention-deficit/hyperactivity disorder and attention problems (AP) in children, adolescents, and adults, as established in the database of the Netherlands Twin Register and increase the understanding of stability in AP across the lifespan as a function of genetic and environmental influences. Method: A…
Descriptors: Attention Deficit Hyperactivity Disorder, Genetics, Foreign Countries, Environmental Influences
Shared Genetic Influences on Negative Emotionality and Major Depression/Conduct Disorder Comorbidity
Tackett, Jennifer L.; Waldman, Irwin D.; Van Hulle, Carol A.; Lahey, Benjamin B. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: To investigate whether genetic contributions to major depressive disorder and conduct disorder comorbidity are shared with genetic influences on negative emotionality. Method: Primary caregivers of 2,022 same- and opposite-sex twin pairs 6 to 18 years of age comprised a population-based sample. Participants were randomly selected across…
Descriptors: Twins, Caregivers, Interviews, Genetics
Martin, Nicolas W.; Benyamin, Beben; Hansell, Narelle K.; Montgomery, Grant W.; Martin, Nicholas G.; Wright, Margaret J.; Bates, Timothy C. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objectives: Breast-fed C-allele carriers of the rs single nucleotide polymorphism in the fatty acyl desaturase 2 ("FADS2") gene have been reported to show a 6.4 to 7 IQ point advantage over formula-fed C-allele carriers, with no effect of breast-feeding in GG carriers. An Australian sample was examined to determine if an interaction between…
Descriptors: Body Weight, Socioeconomic Status, Intelligence Quotient, Interaction
Haworth, Claire M. A.; Plomin, Robert – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To consider recent findings from quantitative genetic research in the context of molecular genetic research, especially genome-wide association studies. We focus on findings that go beyond merely estimating heritability. We use learning abilities and disabilities as examples. Method: Recent twin research in the area of learning…
Descriptors: Learning Problems, Disabilities, Psychiatry, Genetics
Neale, Benjamin M.; Medland, Sarah E.; Ripke, Stephan; Asherson, Philip; Franke, Barbara; Lesch, Klaus-Peter; Faraone, Stephen V.; Nguyen, Thuy Trang; Schafer, Helmut; Holmans, Peter; Daly, Mark; Steinhausen, Hans-Christoph; Freitag, Christine; Reif, Andreas; Renner, Tobias J.; Romanos, Marcel; Romanos, Jasmin; Walitza, Susanne; Warnke, Andreas; Meyer, Jobst; Palmason, Haukur; Buitelaar, Jan; Vasquez, Alejandro Arias; Lambregts-Rommelse, Nanda; Gill, Michael; Anney, Richard J. L.; Langely, Kate; O'Donovan, Michael; Williams, Nigel; Owen, Michael; Thapar, Anita; Kent, Lindsey; Sergeant, Joseph; Roeyers, Herbert; Mick, Eric; Biederman, Joseph; Doyle, Alysa; Smalley, Susan; Loo, Sandra; Hakonarson, Hakon; Elia, Josephine; Todorov, Alexandre; Miranda, Ana; Mulas, Fernando; Ebstein, Richard P.; Rothenberger, Aribert; Banaschewski, Tobias; Oades, Robert D.; Sonuga-Barke, Edmund; McGough, James; Nisenbaum, Laura; Middleton, Frank; Hu, Xiaolan; Nelson, Stan – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of…
Descriptors: Attention Deficit Hyperactivity Disorder, Hospitals, Association Measures, Genetics
Ouellet-Morin, Isabelle; Danese, Andrea; Bowes, Lucy; Shakoor, Sania; Ambler, Antony; Pariante, Carmine M.; Papadopoulos, Andrew S.; Caspi, Avshalom; Moffitt, Terrie E.; Arseneault, Louise – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: Childhood adverse experiences are known to engender persistent changes in stress-related systems and brain structures involved in mood, cognition, and behavior in animal models. Uncertainty remains about the causal effect of early stressful experiences on physiological response to stress in human beings, as the impact of these…
Descriptors: Stress Variables, Twins, Bullying, Emotional Response
Groen-Blokhuis, Maria M.; Middeldorp, Christel M.; van Beijsterveldt, Catharina E. M.; Boomsma, Dorret I. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: Low birth weight (LBW) is associated with attention problems (AP) and attention-deficit/hyperactivity disorder (ADHD). The etiology of this association is unclear. We investigate whether there is a causal influence of birth weight (BW) on AP and whether the BW effect is mediated by catch-up growth (CUG) in low-BW children. Method:…
Descriptors: Attention Deficit Hyperactivity Disorder, Twins, Body Weight, Etiology
Stilp, Rebecca L. H.; Gernsbacher, Morton Ann; Schweigert, Emily K.; Arneson, Carrie L.; Goldsmith, H. Hill – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Twin and family studies of autistic traits and of cases diagnosed with autism suggest high heritability; however, the heritability of autistic traits in toddlers has not been investigated. Therefore, this study's goals were (1) to screen a statewide twin population using items similar to the six critical social and communication items…
Descriptors: Check Lists, Twins, Autism, Toddlers
Hallett, Victoria; Ronald, Angelica; Happe, Francesca – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
The phenotypic and etiologic relation between internalizing and autistic-like traits is studied using a community-based twin sample. Internalizing and autistic-like traits showed moderate phenotypic overlap but have specific genetic influences.
Descriptors: Twins, Genetics, Autism, Symptoms (Individual Disorders)
Fontaine, Nathalie M. G.; Rijsdijk, Fruhling V.; McCrory, Eamon J. P.; Viding, Essi – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To investigate the longitudinal development of callous-unemotional traits (CU) in middle childhood using developmental trajectory analyses in a large twin dataset and examine the degree to which genetic and environmental influences contributed to the CU trajectory-group membership in children. Method: The study included 9,462 youths…
Descriptors: Group Membership, Twins, Females, Early Adolescents
Lynskey, Michael T.; Agrawal, Arpana; Heath, Andrew C. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To provide an overview of the genetic epidemiology of substance use and misuse in adolescents. Method: A selective review of genetically informative research strategies, their limitations, and key findings examining issues related to the heritability of substance use and substance use disorders in children and adolescents is presented.…
Descriptors: Literature Reviews, Children, Heredity, Twins
Wood, Alexis C.; Neale, Michael C. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To describe the utility of twin studies for attention-deficit/hyperactivity disorder (ADHD) research and demonstrate their potential for the identification of alternative phenotypes suitable for genomewide association, developmental risk assessment, treatment response, and intervention targets. Method: Brief descriptions of the classic…
Descriptors: Attention Deficit Hyperactivity Disorder, Research Tools, Structural Equation Models, Clinical Diagnosis
Sugden, Karen; Arseneault, Louise; Harrington, HonaLee; Moffitt, Terrie E.; Williams, Benjamin; Caspi, Avshalom – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Bullying is the act of intentionally and repeatedly causing harm to someone who has difficulty defending him- or herself, and is a relatively widespread school-age phenomenon. Being the victim of bullying is associated with a broad spectrum of emotional problems; however, not all children who are bullied go on to develop such problems.…
Descriptors: Evidence, Emotional Problems, Bullying, Emotional Disturbances
Cole, James; Ball, Harriet A.; Martin, Neilson C.; Scourfield, Jane; McGuffin, Peter – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Objective: Evidence suggests that there is substantial comorbidity between attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder in childhood and adolescence. This study aims to investigate the degree to which etiological factors are shared between the symptoms of these significantly heritable disorders. Method: A twin…
Descriptors: Evidence, Attention Deficit Hyperactivity Disorder, Twins, Females
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