The Clemmensen reduction is a common example of a reaction demonstrating the deoxygenation of carbonyl groups, which is a topic that has been widely studied in the field of organic chemistry. The use of trimethylchlorosilane, as a substitute for concentrated hydrochloric acid, allows for the reduction of carbonyl groups. The Clemmensen reduction…

Laboratory learning in the life sciences is historically centered around following recipe-like instructions to complete activities with defined outcomes. The American Association for the Advancement of Science's "Vision and Change" report has called for a change in science teaching. The report emphasizes the importance of providing…

Enzymes, enzymatic kinetics, and enzyme inhibition are topics covered in undergraduate biochemistry textbooks, having perceptible relevance to everyday life. The experimental use of enzymes involved in basic physiologic processes may be of utmost pedagogic interest because they bring evidence on how a significant number of drugs are used to…

Active learning provides students with meaningful and introspective roles in education. However, active learning is difficult to achieve in online class settings, particularly for biology laboratories initially designed to offer direct interactions with live organisms. During the COVID-19 pandemic, a transition to online learning was required in…

In this study, students' understanding of some important features of competitive elimination and substitution reactions of alcohols was examined based on their participation in a guided inquiry activity of two organic laboratory experiments: the dehydration of cyclohexanol and the conversion of tert-butyl alcohol into tert-butyl chloride. Students…

Scanning probe microscopy such as atomic force microscopy has become increasingly integrated and relevant in undergraduate laboratory investigations. As the "hands and eyes of the nanoworld", atomic force microscopes (AFMs) continue to be used to innovate the nanowriting process for data storage and in the exploration of novel materials…

This undergraduate laboratory experiment is designed for first-year general chemistry students with the goal of introducing the brilliant colors and magnetic properties of transition metal complexes within a bioinorganic/cell biology context. In the first laboratory period, a coordination complex formed from ferric chloride and maltol is…

This research developed learning activities for students to explore and connect the concepts of acid-base titration, equivalence points, pK[subscript a], and molar absorption coefficients. Polyphenolic compounds consisting of p-coumaric acid (CMA), caffeic acid (CFA), and 3,4,5-trihydroxycinnamic acid (3,4,5-THCA) were selected as study models.…

Surface chemistry is a challenging realm for most students because of its abstract nature and numerous associated mathematical equations. Herein we report a set of dedicated sequential inquiry-based learning (IBL) activities enriched with virtual laboratory learning and hands-on instructions. The activities were intended to help students grasp…

Italian high school students carried out some activities within career guidance actions organized by the Department of Chemistry of Sapienza University (Rome) in order to promote enrollments in a chemistry Bachelor's course, thus remedying the shortage of professional chemists. Novel didactic sequences have been designed to facilitate the…

The process of method development is at the heart of analytical chemistry, yet direct experimental experience with the process is rarely taught in the undergraduate laboratory. We report here an experiment that uses rapid, safe, and inexpensive paper-based microfluidics with cell phone detection in order to facilitate the development of a…

The chemistry laboratory is an impactful platform for introducing inquiry and developing science practice skills. We designed a short lab course to introduce incremental levels of inquiry, also to interconnect and integrate different domains of chemistry. Indigo dye was the central theme of this short course wherein students synthesized indigo,…

An undergraduate-level Computational Chemistry project was incorporated initially into a Physical Chemistry course and then into the laboratory curriculum in the subsequent application. Before the introduction of the project, the lectures covered quantum chemistry, spectroscopy, and kinetics while simultaneously including computational chemistry…

This report describes the implementation of a laboratory exercise for an advanced biochemistry or enzyme kinetics class at the undergraduate or graduate level, designed to improve understanding of protein conformational changes associated with the binding of a ligand. Students measure the fluorescence changes induced by the conformational…

Advancements in technology have led to significant changes in the workforce and created a demand for expertise in science, technology, engineering, and mathematics (STEM). In response, curricula have evolved to emphasize essential skills such as critical thinking and communication to prepare students for STEM-based careers. To this end,…