The process of method development is at the heart of analytical chemistry, yet direct experimental experience with the process is rarely taught in the undergraduate laboratory. We report here an experiment that uses rapid, safe, and inexpensive paper-based microfluidics with cell phone detection in order to facilitate the development of a…

Polymer chemistry is an important subject in the undergraduate chemistry curriculum. It is required for ACS-certified degrees and significantly connects to real world issues like the plastic waste crisis. While some concepts of polymer chemistry can be incorporated into lecture courses, students' understanding of material properties and…

This three-part laboratory experiment investigates key aspects of the Buchwald-Hartwig amination cross-coupling reaction through guided-inquiry learning strategies. The first part of this experiment utilizes high-throughput experimentation techniques to reinforce, explore, and extend fundamental concepts that are represented in the classroom,…

Inorganic Chemistry teaches students the concept that modifications to ligand structures, especially the donor properties, can have a drastic impact on the reactivity and stability of the metal complexes. Experiments described here reinforce this concept through the investigation of two tetradentate ligands derived from…

The dehydration of 2- or 4-methylcyclohexanol to obtain isomers of methylcyclohexene is a classic organic chemistry experiment. Students perform a distillation, collecting samples to analyze the progress of the reaction. The reaction produces a major product that can be explained on the basis of the regiochemistry of the [pi] bond formation for…

The free radical chlorination of an alkane experiment is often used in the undergraduate laboratory curriculum to introduce students to the free radical mechanism, substituent effects, intermediate stability, and the relative reactivity of radicals. In this experiment, students monochlorinate multiple alkanes and analyze the reaction mixture using…

This work further implements the "elements of inquiry" approach in a first-year undergraduate laboratory course, in a two-part inquiry sequence. In the first part of the sequence, students iteratively develop a "best-practice" TLC procedure. In the second part, students iteratively optimize a simple organic reaction using TLC,…

In this study, students' understanding of some important features of competitive elimination and substitution reactions of alcohols was examined based on their participation in a guided inquiry activity of two organic laboratory experiments: the dehydration of cyclohexanol and the conversion of tert-butyl alcohol into tert-butyl chloride. Students…

This undergraduate laboratory experiment is designed for first-year general chemistry students with the goal of introducing the brilliant colors and magnetic properties of transition metal complexes within a bioinorganic/cell biology context. In the first laboratory period, a coordination complex formed from ferric chloride and maltol is…

A high performance liquid chromatography (HPLC) experiment for the upper level analytical chemistry laboratory is described. The students consider the effect of mobile-phase composition and pH on the retention times of ionizable compounds in order to determine the acid dissociation constant, K[subscript a], of a phenolic acid. Results are analyzed…

Glycoscience continues to be an underrepresented topic in current undergraduate-biochemistry-laboratory curricula. Of the educational laboratories present in this subject area, few introduce students to cutting-edge methods and techniques related to carbohydrates. A multiweek series of experiments is described that highlights a recently published…

This two-period undergraduate laboratory experiment involves the synthesis of a mixture of isomeric unknowns, isolation of the mixture by means of distillation, and characterization of the two products primarily by NMR spectroscopy (1D and 2D) supported with IR spectroscopy and GC-MS techniques. Subsequent calculation and examination of the…

This two-part laboratory experiment is concerned with investigating key aspects of the Suzuki-- Miyaura cross-coupling reaction. The first part of this experiment utilizes high-throughput experimentation techniques to reinforce, explore, and extend fundamental concepts that are presented in the classroom. In contrast, the second part employs…

Unlike the large number of laboratory experiments on phase-transfer catalysis (PTC) that focus on a catalyzed chemical process, the present laboratory emphasizes the mechanism of phase transfer catalysis itself. Students can follow visually the actual transfer of the reagent by the catalyst, and its consumption in the organic phase, in a…

Acid-base titration concepts and experiments are ubiquitous, yet challenging, aspects of the general chemistry curriculum. Most general chemistry courses include at least one acid-base titration laboratory experiment, though the focus is often on determining the concentration, pK[subscript a], or molar mass of an analyte rather than on the details…