A mixture of salt water and isopropyl alcohol is immiscible, forming two separate liquids with the organic layer on top and aqueous layer on bottom. When universal indicator is added to such a mixture, all of the indicator compounds in the universal indicator preferentially dissolve in the alcohol--except for phenolphthalein at high pH. Mixtures…

The great development of high-throughput molecular biology techniques and the consequent generation of massive data have made Bioinformatics essential for undergraduate Bioscience students. The importance of this scientific discipline is evidenced by the huge number of specialized publications, tools, and databases available. Training in…

The prompt introduction of single-molecule science into undergraduates' curricula is an urgent but challenging task. However, the research experiments are often too complicated and the instruments are too expensive to be widely transferred into a compulsory course of undergraduate students. Herein, we introduce a recently developed nanopore…

Many STEM (science, technology, engineering, and mathematics) disciplines require a two-semester sequence of introductory college chemistry, which are thus critical gateway courses to a variety of majors. Recognizing the benefit to educators of a structure of content learning across the chemistry curriculum, in 2012, the American Chemical Society…

A significant challenge for the global community is the increasing demand for clean and renewable energy technologies. However, a lack of knowledge of these technologies threatens to impede their adoption. The development of cheap, effective, and easy-to-use chemical and electrochemical storage technologies is crucial if countries are to move away…

3D printing was used to prepare space-filling models of electron density isosurfaces and high-resolution molecular models on the basis of the van der Waals radii of atoms. Both model types provide students with kinesthetic simulations of steric effects in bimolecular substitution and elimination reactions. The models can be printed in small sizes…

A safe and inexpensive laboratory for a first-year general chemistry course has been developed which allows students to explore important properties of carbon dioxide, particularly its behavior as a greenhouse gas. Students witness and measure air displacement to compare calculated gas densities and pressures inside a CO[subscript 2]-filled…

Here we present a new undergraduate laboratory that will introduce the concepts of time-resolved spectroscopy and provide insight into the natural time scales on which chemical dynamics occur through direct measurement. A quantitative treatment of the acquired data will provide a deeper understanding of the role of quantum mechanics and various…

An iridium(III)-mediated C-H functionalization sequence involving a concerted cyclometalation-deprotonation/migratory insertion pathway is reported for the undergraduate chemistry laboratory. The air- and water-stable iridacycle intermediates are readily isolated and characterized by NMR spectroscopy. Both steps of the experiment are performed at…

This lab experiment uses [superscript 31]P NMR spectroscopy of biomolecules to determine pK[subscript a] values and the binding energies of metal/biomolecule complexes. Solutions of adenosine nucleotides are prepared, and a series of [superscript 31]P NMR spectra are collected as a function of pH and in the absence and presence of magnesium or…

Bioinorganic topics are ubiquitous in the inorganic chemistry curriculum; however, experiments to enhance understanding of related topics are scarce. In this proposed laboratory, upper undergraduate students assess the biological interaction of molybdenocene dichloride (Cp2MoCl2) with bovine serum albumin (BSA) by fluorescence spectroscopy.…

An integrated laboratory experiment applying concepts and techniques from organic chemistry, inorganic chemistry, and instrumental analysis is presented for use in the undergraduate curriculum. This experiment highlights the synthesis, characterization, and use of tris(2-pyridylmethyl)amine (TPMA) to make complexes with different metal salts. It…

Recent advances in spectroscopy and computational chemistry facilitate the introduction of current spectroscopic and computational methods at the undergraduate level. Students obtain and analyze experimental and calculated vibrational spectra (infrared and Raman) of a set of alkyne molecules to determine the role of symmetry with respect to gross…

This experiment prepares a large (M[subscript r]: 1821 g mol[superscript -1]) triple helicate complex quickly in one pot from inexpensive starting materials. The protocol illustrates the power of self-assembly in a simple manner that is suitable for second-year general chemistry students using reversible imine bond and metal-ligand bond formation.…

This work describes the use of a single chemical reaction to teach and connect a number of standard general chemistry course topics while also introducing students to polymer concepts. Through the study of the reaction that converts spiropyran into merocyanine, we are able to present and connect molecular orbital theory, quantum mechanics,…