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Direct linkJanus, Christopher – Learning & Memory, 2004
TgCRND8 mice represent a transgenic mouse model of Alzheimer's disease, with onset of cognitive impairment and increasing amyloid-[beta] plaques in their brains at 12 weeks of age. In this study, the spatial memory in 25- to 30-week-old TgCRND8 mice was analyzed in two reference and one working memory Morris water maze (MWM) tests. In reference…
Descriptors: Pathology, Nonverbal Learning, Spatial Ability, Learning Strategies
Vuckovich, Joseph A.; Semel, Mara E.; Baxter, Mark G. – Learning & Memory, 2004
A recent study suggests that lesions to all major areas of the cholinergic basal forebrain in the rat (medial septum, horizontal limb of the diagonal band of Broca, and nucleus basalis magnocellularis) impair a spatial working memory task. However, this experiment used a surgical technique that may have damaged cerebellar Purkinje cells. The…
Descriptors: Neurological Impairments, Animals, Short Term Memory, Spatial Ability
