Accelerated longitudinal designs (ALDs) provide an opportunity to capture long developmental periods in a shorter time framework using a relatively small number of assessments. Prior literature has investigated whether univariate developmental processes can be characterized with data obtained from ALDs. However, many important questions in…

This study investigates the neurocognitive underpinnings of early language learning in adults and examines the modulating effects of individual differences in prior bilingual experience and cognitive capabilities. This study used a pre/post short-term longitudinal design with a 10-day Dutch language training via Rosetta Stone. Event-Related…

For a century, America's early childhood policy has been premised on a myth. This falsehood--which dictates that child care and education are somehow separate and distinct--not only suboptimizes the most important window into all human development, but costs American taxpayers an untold fortune. It's time to think differently. Written in plain yet…

In this thesis, I use a combination of simulations and empirical data to demonstrate that a small set of structural and functional principles - the basic tenets of predictive coding theory - succinctly accounts for a very wide range of properties in the language processing system. Predictive coding approximates hierarchical Bayesian inference via…

The decision to move away from lecture-led instruction in the college classroom is not simple. Planning for and managing a more interactive classroom brings unique challenges and opportunities. A biomechanics instructor and an instructional designer from Utica University compared teacher-led instruction to brain-based instruction and share their…

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction, verbal and nonverbal communication, and behaviors or interests. Besides behavioral, psychopharmacological and biomedical interventions there is increasing evidence of non-invasive treatments like neurofeedback (NFB) that can improve brain…

Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence…

Purpose: Stuttering is characterized by intermittent speech disfluencies, which are dramatically reduced when speakers synchronize their speech with a steady beat. The goal of this study was to characterize the neural underpinnings of this phenomenon using functional magnetic resonance imaging. Method: Data were collected from 16 adults who…

Remembering is not a static process: When retrieved, a memory can be destabilized and become prone to modifications. This phenomenon has been demonstrated in a number of brain regions, but the neuronal mechanisms that rule memory destabilization and its boundary conditions remain elusive. Using two distinct computational models that combine…

In an ever-changing environment, survival depends on learning which stimuli represent threat, and also on updating such associations when circumstances shift. It has been claimed that humans can acquire physiological responses to threat-associated stimuli even when they are unaware of them, but the role of awareness in updating threat…

Human cognition exhibits a striking degree of variability: Sometimes we rapidly forge new associations whereas at other times new information simply does not stick. Correlations between neural activity during encoding and subsequent retrieval performance have implicated such "subsequent memory effects" (SMEs) as important for…

Key areas of the episodic memory (EM) network demonstrate changing structure and volume during adolescence. EM is multifaceted and yet studies of EM thus far have largely examined single components, used different methods and have unsurprisingly yielded inconsistent results. The Treasure Hunt task is a single paradigm that allows parallel…

Most studies of molecular mechanisms of synaptic plasticity have focused on the sequence of changes either at individual synapses or in the cell nucleus. However, studies of long-term facilitation at "Aplysia" sensory neuron--motor neuron synapses in isolated cell culture suggest two additional features of facilitation. First, that there…

The propensity to use a spatial framework to organize other pieces of information is a widespread phenomenon that permeates humans' representation of diverse concepts, including numerical quantities. Developmental studies on numerical cognition have revealed that humans possess a system for abstract quantity representation that is functional at…

Beta-adrenergic receptors ([beta]-ARs) prime hippocampal synapses to stabilize long-term potentiation (LTP). This "metaplasticity" can persist for 1-2 h after pharmacologic activation of [beta]-ARs. It requires activation of PKA (cAMP-dependent protein kinase) during [beta]-AR priming. A-kinase anchoring proteins (AKAPs) tether PKA to…