Objective: This study examined whether distinct mindfulness profiles explain physical health complaints common among college students. Participants: Participants were 535 college students. Methods: Participants completed the Five Facet Mindfulness and Physical Health Questionnaires. Latent profile analysis and the Bolck-Croon-Hagenaars method examined whether mindfulness profiles uniquely explained sleep disturbances, headaches, gastrointestinal problems, and respiratory illness symptoms. Results: Three mindfulness profiles were identified: Judgmentally Observing, Average Mindfulness, and High Mindfulness/Nonjudgmentally Aware. The High Mindfulness/Nonjudgmentally Aware profile students tended to report having the best physical health (i.e., fewer sleep disturbances, headaches, gastrointestinal problems, and respiratory illness symptoms). Conversely, students with the Judgmentally Observing profile reported the worst physical health outcomes (i.e., more sleep disturbances, headaches, gastrointestinal problems, and respiratory illness symptoms). Conclusions: By exploring the associations between mindfulness profiles and physical health outcomes, this study offers a deeper understanding of the impact targeting specific mindfulness skills can have for promoting college student health.