The Meerwein reaction is often omitted from undergraduate organic chemistry laboratory books. This experiment, the preparation of "o"-chlorocinnamic acid from "o"-chloroanaline, illustrates this section. (BB)

This safe and efficient procedure for the synthesis of N-substituted amides and hydrazides is a modification of the Schotten-Bausmann procedure in which the amine or hydrazide is replaced by the corresponding hydrochloride salt, and the use of alkali is eliminated. (Author/BB)

Describes the contributions of Justus Liebig to the field of agricultural chemistry. (SL)

Describes a Personalized System of Instruction (PSI) first year organic chemistry course. (SL)

Described is a modified Fehling test and a modified corrected Benedict test. (RH)

Experiments involving the coupling of alkyl and aryl halides in the presence of lithium metal and ultrasound are described. The experiments illustrate classical Wurtz and Fittig reactions in addition to being a convenient application of organic sonochemistry. (JN)

Presents the synthesis of the science of enzymology from application of the concepts of physical organic chemistry from a historical perspective. Summarizes enzyme and coenzyme mechanisms elucidated prior to 1963. (JM)

Reviews recent developments in synthetic organic sonochemistry, focusing on reactions involving metals. Cites important historical findings, discusses cavitation effects, and describes important reactions. (JM)

Shows that electronic structure diagrams make more accurate predictions of spectral properties and chemical reactivity for simple pi systems than do either Huckel molecular orbital or valence bond theory alone. Topics addressed include absorption and photoelectron spectra, spin density distribution in radicals, and several problems regarding…

Describes a new way of quantifying organic oxidation-reduction reactions that extends the traditional method of assigning oxidation numbers by replacing them with NORM's (Number of Oxidations Relative to Methylene). This modification allows the system to be applied to more complex examples without the cumbersomeness inherent in the original…

Summarizes a symposium which focused on the problems with declining performance in the introductory organic chemistry course, analysis of their causes, and suggestions for overcoming them. Symposium attendees included 65 organic chemistry teachers from two- and four-year institutions in Nebraska and neighboring states. (JN)

Two experiments in which an enzyme is immobilized onto a polymeric support are described. The experiments (which also demonstrate two different polymer preparations) involve: (1) entrapping an enzyme in an acrylamide polymer; and (2) reacting the amino groups on the enzyme's (esterase) lysine residues with an activated polymer. (JN)

Discusses trends in hydroformylation chemistry, considering these catalysis and ligands: (1) cobalt, (2) cobalt-phosphine, and (3) rhodium-phosphine. Indicates that rhodium technology will grow in domination of hydroformylation practice. In addition, processes adapted to special cases of functional olefins and to higher olefins can be expected.…

The hydrocyanation of butadiene provides an excellent route to adiponitrile, a nylon precursor. The detailed mechanistic studies that made the development of this technology possible are discussed. (JN)

Shows how olefin isomerization and the exotic olefin metathesis reaction can be harnessed in industrial processes. Indicates that the Shell Higher Olefins Process makes use of organometallic catalysts to manufacture alpha-olefins and internal carbon-11 through carbon-14 alkenes in a flexible fashion that can be adjusted to market needs. (JN)