Recent investigations show that the ipso position competes effectively with unsubstituted positions in many aromatic substitution reactions, regardless of charge type of reaction. Selected examples available for nucleophilic, electrophilic, and free radical reactions are reviewed to suggest the range of ipso reactions. (JN)

Discusses a simple, effective way of teaching S and R configurations for chiral molecules containing asymmetric centers. The method involves converting wedge/spatial representations to Fischer projections and prioritizing groups according to the Cahn-Ingold-Prelog sequence rules. Two examples illustrating the method are included. (JN)

In representing conformational equilibria of compounds having only one chiral center, erroneous formulas showing different antipodes on the two sides of the equilibrium are rare. In contrast, with compounds having two or more chiral centers especially with saturated heterocycles, this erroneous representation occurs frequently in the chemical…

Describes a method for specifying R/S (clockwise/counterclockwise) configuration about a chiral center which does not require the use of a three-dimensional physical model, the mental visualization of the molecule, or the memorization of a recently reported arbitrary number system. (Author/JN)

Use of phase transfer agents to facilitate/accelerate chemical reactions has become an established practice, particularly in organic chemistry. Describes an undergraduate laboratory procedure demonstrating the principles involved in the use of said agents. Includes student results from phase transfer assisted permanganate oxidations. (Author/JN)

Of interest in this discussion of organometallic complexes are stoichiometric or catalytic reagents for organic synthesis in the complex transformations observed during synthesis for transition metal organometallic complexes. Detailed are general reaction types from which the chemistry or many transition metal organometallic complexes can be…

Results of a two-year study of college students (N=103, year one and N=90, year two) suggest that a weekly quiz, compared to a frequency of one quiz every two weeks, is an excellent tool to stimulate learning in a year-long organic chemistry course. (Author/SK)

An approach to the teaching of bonding and orbitals in college organic chemistry courses is described. (BB)

Discusses the thermodynamics and kinetics of cycloamylose complexation and the use of cycloamyloses to illustrate enzyme active site and spectroscopic studies. (MLH)

Discusses the reasons why molecules for which two or more canonical structures can be drawn are more stable than those for which only one structure can be drawn. (MLH)

Describes a student team learning method used in an organic chemistry class at Armstrong Atlantic State University. The Student Teams Achievement Divisions (STAD) method was used in this study. Discusses cooperative learning methods in organic chemistry classes. (KHR)

Discusses the use of the mixture of a carboxylic acid and sodium borohydride as a reagent. The chemical mechanism of the mixture is described using structural formulas. Lists 15 references. (YP)

Presents an effective means of determining the R or S configuration of chiral molecules using the Cahn Ingold Prelog (CIP) sequence rules to establish substituent priority and use of the ultimate model of chirality, the hands, to aid in the direct correlation and assignment of relative configuration. (ZWH)

Uses an interdisciplinary approach in an organic chemistry course which integrates a pharmacology framework to incorporate meaningful connections between biology and chemistry. (YDS)

Provides an annotated bibliography of text resources for the study and teaching of organic chemistry. (Author/MM)