The ability to express scientific concepts in mathematical terms and integrate scientific and mathematical reasoning about a phenomenon is a foundational cognitive process involved in scientific thinking. This process called "blended math-science sensemaking" (MSS) is a desired skill for all science, technology, engineering, and math…

While teacher education programs have long studied what draws students to choose a career in teaching, a less studied aspect of teacher candidates relates to students who change majors to become teachers. As a phenomenon that is common in teacher preparation, I am interested in better understanding why this happens. This article centers around six…

An understanding of structure-function relationships in proteins is essential for modern biochemical studies. The integration of common freely accessible bioinformatics tools available online with the knowledge of protein-engineering tools provide a fundamental understanding of the application of protein structure-function for biochemical…

Purpose: This article presented the results of studies that examined the appropriateness of the content, readability of printed learning materials and the effectiveness of external resources in ecology course offered at Universitas Terbuka. To integrate external resources, links to their websites were provided in the printed materials.…

The development of equitable grading systems that provide students with effective feedback and provide instructors with an efficient means of assessment are of deep interest to chemical educators. A recent trend in chemical education, and STEM education more broadly, has been the use of specifications, or specs, grading that emphasizes mastery of…

An efficient synthesis of the exorbitantly priced Lambert-Eaton myasthenic syndrome drug amifampridine was developed and applied in the second-semester undergraduate organic chemistry laboratory. The two-step synthesis entails a nucleophilic aromatic substitution reaction of commercial 4-chloro-3-nitropyridine with methanolic ammonia to afford…

The carbonyl group of an aldehyde or ketone reacts with different types of nucleophiles through a nucleophilic addition reaction. When the nucleophile is water, the product obtained is a "gem"-diol or geminal diol. This functionalization is unstable and quickly reverts to the parent carbonyl group. The chemistry of "gem"-diols…

The number of studies analyzing chemistry textbooks has steadily increased over the years and has notably surged in the past decade. In this literature review, we examine the research literature on chemistry textbooks. The review spans 40 years of research (from 1981 to 2021) and includes 79 studies published in over 20 different journals,…

A one-pot multicomponent synthesis of unsymmetrical indole-substituted methane derivative based on two consecutive reactions of p-methylbenzaldehyde with N-methylindole and 5,5-dimethyl-1,3-cyclohexanedione is described as an experiment that was carried out by second-year undergraduate chemistry students individually in a laboratory classroom. The…

We conducted a study with introductory and upper-division physics students in a Mexican university to learn how students independently recognize the electric field's main characteristics in the electric field lines diagram and as a source or target representation in conversion processes. We used the theory of registers of semiotic representations…

S[subscript N]2 reactions are of fundamental importance in introductory organic chemistry courses, and a number of experiments suitable for the first-semester undergraduate organic lab have been previously reported. Most of these experiments have used alkyl halides as electrophiles, but alkyl halides are often less than ideal for reasons of…

Discussions of the primary literature are an important part of undergraduate education, and much work has been done to develop methods of integrating the literature into the curriculum. Examples include individual single-article discussion activities, literature-based courses, and regular journal club events. While many published examples focus on…

A [beta]-lactam, the core structure unit of clinically important antibiotics such as penicillin and cephalosporin, is one of the most commonly encountered four-membered heterocycles in organic chemistry and is widely used in medicine and biochemistry. The Kinugasa reaction, a copper­(I)-catalyzed cycloaddition of a terminal alkyne with a nitrone,…

Apurinic/apyrimidinic (AP or abasic) sites are deoxyribonucleic acid (DNA) lesions that result from the loss of a nucleobase by hydrolysis of the "N"-glycosyl bond. AP sites are the most frequent lesions in cells and are caused by environmental and cancer therapeutic genotoxins. Herein, the bicinchoninic colorimetric assay, typically…

Quantitative analysis in analytical chemistry is divided into semi-,relative, and absolute analysis. An example of each analysis is pH test paper, internal standard, and standard addition, respectively. However, their definition and differences have not yet been explained to students sufficiently in classes as well as textbooks. Polymerase chain…