A broadly applicable semester-long course-based undergraduate research experience (CURE)-inspired organic II laboratory course was developed from an engaging story supported by the current literature surrounding paraben use in consumer products. The project involves the synthesis of brominated parabens followed by an investigation into the…

This manuscript describes the implementation of a Course-based Undergraduate Research Experience (CURE) sequence in chemistry that uses research to link a lower division, organic chemistry course to an upper-division, analytical chemistry course. In the CURE sequence, students created a library of modified sugar molecules during CURE-1, Organic,…

Fractional distillation is part of the essential experimental techniques taught to first-year chemistry students, especially during practical organic chemistry work. The characterization of the distillate generally involves measuring the boiling temperature, the refractive index, or the infrared spectrum. In this paper, an unknown mixture composed…

Collaborative experiences have been widely integrated into the classroom and laboratory, with goals to build time management, communication, and team-working skills. Most reported laboratory collaborations occur between students within the same lab section, which could limit the potential benefits of these experiences. Presented herein is an…

Self-regulated learners strategically manage physical, technological, online, and social resources for learning--by selecting resources that could be useful, reflecting on how useful these resources have been, and adjusting resource use accordingly. We propose a model that conceptualizes resource management as learners' intentional,…

Large, multisection laboratory courses are particularly challenging when managing grading with as many as 35 teaching assistants (TAs). Traditional grading systems using point-based rubrics lead to significant variations in how individual TAs grade, which necessitates the use of curving across laboratory sections. Final grade uncertainty…

To potentially engage students in "doing organic chemistry", organic chemistry courses should foreground weaving together structure- and energy-related ideas to construct causal accounts for phenomena. Here, we investigate whether enrolling in an organic chemistry course that places substantial emphasis ([approximately]50% of total…

Organic chemistry courses enroll students from many majors with diverse interests. Although instructors may strive to appeal to these interests by relating course content to real life, it is challenging to intrinsically appeal to students at the personal level, particularly in high enrollment courses like organic chemistry. When students identify…

Productive problem solving, concept construction, and sense making occur through the core process of abstraction. Although the capacity for domain-general abstraction is developed at a young age, the role of abstraction in increasingly complex and disciplinary environments, such as those encountered in undergraduate STEM education, is not well…

Previous research on student argumentation in the chemistry laboratory has emphasized the evaluation of argument quality or the characterization of argument structure (i.e., claims, evidence, rationale). In spite of this progress, little is known about the impact of the wide array of factors that impact students' argumentation in the undergraduate…

Three different experiments that allow the synthesis of the drug paracetamol are described; such experiments were designed for their implementation in undergraduate organic chemistry courses, considering the medical and economic importance of paracetamol. The experience wants to show the students some "real world" applications of organic…

A new undergraduate organic laboratory experiment has been developed and implemented for the Ugi three-component synthesis of the topical anesthetic lidocaine with excellent atom economy. Paraformaldehyde, diethylamine, and 2,6-dimethylphenyl isocyanide were combined and conveniently stirred at room temperature for a week in methanol with acetic…

Undergraduate organic chemistry laboratory courses act as a baseline for introductory scientific experimentation. These courses provide students with the knowledge and skills for their future careers. The traditional lab is conducted by providing a structured protocol of the experiment for the students to follow and reproduce the assigned task…

A new undergraduate organic laboratory experiment has been developed for amide bond formation between biorenewable 2-furoic acid and either of two substituted piperazines to prepare medicinally relevant amide products using a procedure with industrial significance. The reactions proceeded smoothly under ambient conditions using the combination of…

Organic chemistry is a cognitively demanding subject with persistently low student achievement. This review aimed to identify instructional strategies and educational technologies used to improve learning outcomes in organic chemistry across educational levels and learning environments. A systematic review of 40 experimental studies (2014-2023)…