Radical chemistry is an essential part of the organic chemistry curriculum. Free radical halogenation experiments provide an excellent opportunity to introduce important topics related to the outcome and mechanism of organic reactions. In this communication, a green photochemically activated benzylic bromination of p-toluic acid is described. In…

Due to a growing awareness of environmental issues, green chemistry concepts are increasingly being incorporated into the undergraduate organic chemistry lecture and laboratory component. This minireview summarizes environmentally friendly organic chemistry experiments suitable for undergraduate laboratories. Whenever feasible, LD[subscript 50]…

The bromination of six isomeric alcohols is adapted to a discovery-based organic chemistry laboratory experiment, whereby students are provided an alcohol starting material and are charged with determining the product or product mixture produced using relevant spectroscopic data. The experiment solidifies NMR analysis skills while reinforcing the…

This three-part laboratory experiment investigates key aspects of the Buchwald-Hartwig amination cross-coupling reaction through guided-inquiry learning strategies. The first part of this experiment utilizes high-throughput experimentation techniques to reinforce, explore, and extend fundamental concepts that are represented in the classroom,…

In a world facing complex global challenges, citizens around the world need to be able to engage in scientific reasoning and argumentation supported by evidence. Chemistry educators can support students in developing these skills by providing opportunities to justify how and why phenomena occur, including on assessments. However, little is known…

A traditional laboratory course with the primary learning outcome of improving students' theoretical knowledge has received much criticism over the years due to the lack of evidence that these goals have achieved. We report our efforts to redesign a traditional first-year organic and inorganic (also known as synthetic) laboratory course from…

In the USA, Organic Chemistry I is a gateway course for undergraduate students seeking careers in medical- and health-related fields. Estimates of failure and withdrawal rates are approximately 40% at some large, public institutions and higher for specific segments of the student population, such as ethnic minorities, those of low socio-economic…

Iodonium zwitterions are hypervalent iodine compounds in which the iodine center binds to two substituents and carries a positive formal charge which is compensated by a negative charge within the same molecule. Under thermodynamic conditions, iodonium zwitterion sallow concerted nucleophilic aromatic substitutions to be performed, followed by…

The effects of kinetic vs thermodynamic control on "endo"/"exo" stereoisomer ratios can be observed in a simple Diels-Alder reaction between "N"-phenylmaleimide and furan. The use of microwave-promoted synthesis affords the cycloadducts in yields ranging from 65-100%, employing reaction times of 1-10 min at…

Some research works have showed that Ghanaian teachers, teaching chemistry in the senior high school, have conceptual difficulties in organic chemistry. This research explored the factors contributing to teacher's conceptual difficulties on teaching organic chemistry to high school students. Through explanatory sequential mixed methods design…

Acid-base chemistry, and in particular the Lewis acid-base model, is foundational to understanding mechanistic ideas. This is due to the similarity in language chemists use to describe Lewis acid-base reactions and nucleophile-electrophile interactions. The development of artificial intelligence and machine learning technologies has led to the…

In this study, a new competency assessment system was developed for the blended learning course "Organic Chemistry Laboratory". The system utilized a mastery transcript evaluation model and incorporated the Structure of Observed Learning Outcomes (SOLO) taxonomy and Primary Trait Analysis (PTA) scale method. With this system, students…

Teaching and learning became more challenging during the COVID-19 pandemic as classes moved online for both remote and hybrid learning. For hybrid learning, instructors harnessed various technologies to facilitate student-teacher engagement. Here we explored the use of an online collaborative platform, Miro Board, to aid teaching of organic…

Equal access to an instructor's time and attention can be a barrier experienced by many underrepresented minorities. An instructor's own biases will determine the nature of their interaction with students, and even well-meaning instructors can interact with students in differential ways, which might prevent certain students from having access to…

A national survey of chemists (n = 174) explored the self-reported format and focus of postsecondary inorganic chemistry instructional laboratory curricula. Multiple instructional laboratory course formats were observed, including stand-alone inorganic chemistry instructional laboratory courses, inorganic chemistry laboratory instruction as a…