Describes an alternative medical school curriculum for the first two years of preclinical basic science studies. Discusses student and faculty selection for the program. Details the format for teaching biochemistry in the Alternative Curriculum, including program structure, content organization and exams. Evaluates the success of the program. (CW)

Ribonucleic acid (RNA) converts genetic information into protein and usually must be processed to serve its function. RNA types, chemical structure, protein synthesis, translation, manufacture, and processing are discussed. Concludes that the first genes might have been spliced RNA and that humans might be closer than bacteria to primitive…

Describes current methods for the synthesis of DNA. Also describes the use of DNA as a highly specific molecular probe and as an agent for the mutation of genes. (DH)

Outlines use of electrode potential diagrams in a simple system and in the Hill-Bendall scheme for photosynthesis to help students understand reaction mechanisms involved. Emphasizes use of arrows to depict electron transfer, concept of free-energy diagram, and that maximum heights on diagrams represent maximum work available/minimum work…

Discusses the diversity and dynamic nature of the chemical components of postharvest crops. Also discusses the role of respiration and genetic control in chemical transformations leading to desirable and undesirable changes in the quality of edible plants after harvest. The role of enzymes in producing these changes is considered. (JN)

Describes two computer programs (BASIC for 32K Commodore PET) for teaching protein synthesis. The first is an interactive test of base-pairing knowledge, and the second generates random DNA nucleotide sequences, with instructions for substitution, insertion, and deletion printed out for each student. (JN)

Describes an experimental biochemistry course designed to teach basic biochemical techniques using an unstudied enzyme as the experimental material. Explains the schedule of experiments designed for the course and lists the sources used. (GS)

Discusses experimental evidence for the existence of organic material in the solar system prior to the earth's formation. Indicates that the earth could have received much of its organic compounds from meteors falling on its primitive surface. (CC)

Describes common artificially produced organized media such as colloids, surfactants, and polymers and their usefulness in studying complex biochemical processes. Discusses selected recent photophysical and photochemical exploitations of these systems, including artificial photosynthesis, in situ generation of colloidal gold and platinum,…

Electrochemical studies can give insights into the chemical aspects of enzymatic and in vivo redox reactions of naturally occurring organic compounds. This is illustrated by studies of the electrochemical oxidation of the purinem uric acid. The discussion is limited to information at pH 7 or greater. (JN)

Reviews the physiological effect of acute grief and explores the increased susceptibility to infectious disease agents in terms of the altered biochemistry of the bereaved individual. Until basic reactions of grief are defined and the altered biochemistry established, psychological methods appear to offer the best therapy. (Author/JAC)

Reviews various provisions of a five-year, $23.5-million research agreement between Washington University and the Monsanto Company. The scientific focus of this venture will be on proteins and peptides which modify cellular behavior. (SK)