One application of modeling is studying the ways in which molecules fit together to form chemical compounds. Describes the forces acting between molecules and how three-dimensional graphical modeling is employed in developing rational principles for drug design. (JN)

Various topics on the biochemistry of genetic manipulation are discussed. These include genetic transformation and DNA; genetic expression; DNA replication, repair, and mutation; technology of genetic manipulation; and applications of genetic manipulation. Other techniques employed are also considered. (JN)

The log C-pH diagram is a useful means of displaying quantitatively the many variables (including temperature) that determine acid-base equilibria in biological systems. Presents the diagram as extended to open/closed biological systems and derives a new water-ion balance method for determining equilibrium pH. (JN)

Describes a computer program designed to simulate the regulation of acid-base balance, emphasizing regulatory compensations involved in the total process. Includes discussion of equations involved, a sample run of the program, and program listing (MicroSoft Basic). (JN)

Discusses the role and use of microcomputers in scientific research, from monitoring instruments to controlling experimental processes. Included are descriptions of a computer-controlled protein sequencer and gene synthesizer, and microcomputer uses in medicine, physiology, biochemistry, and geology. (JN)

Briefly reviews the early history of industrial microbiology and discusses industrial fermentation practices and the role of recombinant DNA in the fermentation industry. (SK)

Thirty medical students at the University of Otago were randomly chosen to learn clinical biochemistry by the Keller Plan. The rest of the class acted as controls. The randomly selected Keller group scored significantly higher than the control group on a practice/review test and the final examination. (Author/MLW)

Biochemical engineering as a scientific discipline is becoming accepted in England and is drawing many young men and women to its ranks. This article focuses on how engineering came to embrace the biological sciences. (Author/SA)

Presents a collaborative learning exercise intended to teach the unfamiliar terminology of experimental design both in biology classes and biochemistry laboratories. The exercise promotes discussion and debate, develops communication skills, and emphasizes peer review. The effectiveness of the exercise is supported by student surveys. (SOE)

Presents an historical perspective on the teaching of biochemistry in Hungary starting during the Austrian-Hungarian Empire. Discusses integration and interdisciplinarity in terms of what should be included in the lecture material and what can be borrowed from other closely related subjects without excessive overlapping. Highlights differences…

Discussed is the Human Genome Project which aims to decipher the totality of the human genetic information. The historical background, the objectives, international cooperation, ethical discussion, and the role of UNESCO are included. (KR)

Presented are two cases of simple geometrical calculations involving the large numbers of atoms that are encountered in two ordinary situations. Included are questions about the spatial implications of the genome and a mole of hydrogen. (CW)

Described are the composition, design, administration, and evaluation of practical examinations. A table of the composition of biochemical unknowns for analysis in practical examinations is included. (CW)

A laboratory experiment designed as a model for studying enzyme activity with a basic spectrometer is presented. Included are background information, experimental procedures, and a discussion of probable results. Stressed is the value of the use of Nuclear Magnetic Resonance in biochemistry. (CW)

Discussed is the evolution of aerobic organisms from anaerobic organisms and the accompanying biochemistry that developed to motivate and enable this evolution. Uses of oxygen by aerobic organisms are described. (CW)