In traditional introductory biochemistry laboratory classes students learn techniques for protein purification and analysis by following provided, established, step-by-step procedures. Students are exposed to a variety of biochemical techniques but are often not developing procedures or collecting new, original data. In this laboratory module,…

A discovery-based Grignard experiment for a second-year undergraduate organic chemistry course is described. The exclusive Grignard reagent formed by the reaction of 1-bromo-4-fluorobenzene (1) with Mg is 4-fluorophenylmagnesium bromide (2), which is treated with either benzophenone or CO[subscript 2] to produce the corresponding fluorinated…

In this laboratory experiment, students synthesize 3-methyl-4-(4-methylbenzoyl)-1-phenyl-pyrazol-5-one by selective C-acylation of 3-methyl-1-phenyl-1H-pyrazol-5-one. Calcium hydroxide is used to push the tautomeric equilibrium toward the enol form, to protect the hydroxyl functionality as a complex, to trap the liberated hydrogen chloride, and to…

This inquiry-based experiment is designed for organic or biochemistry undergraduate students to deduce the identity of phospholipids extracted from chicken eggs and dietary supplements. This is achieved using thin-layer chromatography (TLC) data, a series of guided questions of increasing complexity, and provided relative retention factor (Rf)…

Improving the scientific literacy of non-scientists is an important aim, both because of the ever-increasing impact of science on our lives and because understanding science enriches our experience of the natural world. One route to improving scientific literacy is via general education undergraduate courses--i.e. courses for students not majoring…

Darwin's theory of evolution is explicitly competitive, yet co-operation between individuals is a common phenomenon. The Prisoner's Dilemma model is central to the teaching of the evolution of co-operation. The best-known explorations of the Prisoner's Dilemma are the tournaments run by Robert Axelrod in the 1980s. Aimed at students of biological…

Students who enter college with a solid grounding in, and positive attitudes toward, evolutionary science are better prepared for and achieve at higher levels in university-level biology courses. We found highly significant, positive relationships between student knowledge of evolution and attitudes toward evolution, as well as between…

Despite the large body of evidence that indicates activity-based instruction is more effective than lecture-only instruction, for the purpose of workload calculation, many community colleges assign less value to the time spent in science lab than in lecture. This discrepancy is inconsistent with goals of science excellence set by the National…

In this paper, the authors discuss the effectiveness of MOOCs as part of a pedagogical strategy aimed at supporting Physics' preliminary undergraduate students in large-size lectures. Our study is based on an experimental activity based on a blended course, which integrated a parallel MOOC delivered through the POK (PoliMi Open Knowledge,…

Pearson sought to explore whether the use of Mastering Biology, an online tutorial system used in higher education general introductory courses, is related to students' exam results. This Research Report presents findings from one research study: a correlational study we conducted at a North American state-related, land-grant, doctoral university,…

A simple adaptation of traditional "chemistry kit" condensers for the organic chemistry teaching laboratory is described. These waterless condensers have been employed safely with most solvents. They can be easily fabricated, stored, and used in the same manner as water-cooled condensers. These condensers were utilized in several…

"In situ" hybridization is a widely used technique for studying gene expression. Here, we describe two experiments addressed to postgraduate genetics students in which the effect of transcription factors on gene expression is analyzed in "Drosophila embryos of different genotypes by whole-mount in situ hybridization. In one of the…

Engaging freshman and sophomore students in meaningful scientific research is challenging because of their developing skill set and their necessary time commitments to regular classwork. A project called the Chondrule Analysis Project was initiated to engage first- and second-year students in an initial research experience and also accomplish…

The usefulness of the JANAF tables is demonstrated with specific equilibrium calculations. An emphasis is placed on the nature of standard chemical potential calculations. Also, the use of the JANAF tables for calculating partition functions is examined. In the partition function calculations, the importance of the zero of energy is highlighted.

Undergraduate students in the teaching laboratory have successfully used N-heterocyclic carbenes (NHCs) as organocatalysts for the acetylation of primary alcohols, despite the high water sensitivity of uncomplexed ("free") NHCs. The free NHC readily reacted with chloroform, resulting in an air- and moisture-stable adduct that liberates…