A chemistry course designed as an elective for chemistry, biochemistry, biology, and pharmaceutical science majors is described. The course is designed for second- through fourth-year undergraduate students. The prerequisite is first-semester, second-year undergraduate organic chemistry with the second semester of the organic sequence as a…

The non-major's two-semester organic chemistry course at UPR-RP aims at developing a more integrated and meaningful understanding of the fundamentals of Organic Chemistry. To achieve this goal, we have implemented a novel instructional design that focuses on nine terminal objectives. The nine terminal objectives describe what students should be…

Effectively mastering organic chemistry means having the ability to recognize structural patterns, identify properties or behaviors as a result of patterns, manipulate and transform representations, and predict future outcomes. Often students rely on rote memorization of seemingly disconnected information instead of developing a sound…

The dissertation is composed of two sections. The first section is composed of chapters one, two, and three and describes the study of macrocyclic [beta]-hairpin peptides derived from [beta]-sheet peptides. The second section is composed of chapters four and five and discusses the curricular innovations made to support the remote instruction of an…

Question-embedded videos (QEVs) are learning tools that require students to solve problems and receive immediate targeted feedback while progressing through the video. As an effective learning modality, QEVs may be deployed for the preclass preparation phase of flipped classrooms. As flipped classrooms become more popular in STEM courses,…

This sixth-form chemistry activity describes how students can use acid-base titrimetry to investigate how adding salt to the aqueous phase may change the value of the partition coefficient of an organic acid between water and 2-methylpropan-1-ol. While the presence of lithium chloride and sodium chloride increases the value of the partition…

A concern about students' conceptual difficulties in organic chemistry prompted this study. It was found that prior knowledge from general chemistry was critical in organic chemistry, but what were some of the concepts that comprised that prior knowledge? Therefore an analysis of four years of organic chemistry quiz data was undertaken. Multiple…

A series of organic chemistry synthesis problem sets were provided to students. Potential solution pathways and strategies were recorded on video by the instructor and provided to students electronically via YouTube. Performance on the end-of-semester synthesis exam showed significant gains, with the average increasing by 13% after the…

A robust laboratory protocol for the three-step synthesis of "p"-tolyl 2,3,4,6-tetra-"O"-benzoyl-1-thio-[beta]-d-glucopyranoside from commercial glucose pentaacetate is reported. The previously reported procedures have been modified to accommodate laboratories and students without proper training or equipment needed to conduct…

Constructing and critiquing evidence-based claims is centrally important to aspiring medical professionals and to scientists more generally. Accordingly, The National Academy of Science's "Framework for K-12 Science Education" describes engaging in argument from evidence as one of the practices that characterize work in science. However,…

The VSEPR model has well-established limitations in its ability to represent accurate molecular and electronic geometries of simple molecules, which can create a significant need for students to relearn structure and bonding concepts in organic chemistry. We present an alternate method for describing molecular geometries and electronic structures…

The study presented here is a follow-up to a previous report in which we investigated how general-chemistry students in a transformed curriculum reason about simple acid-base reactions. In the present study, we use and adapt the previously developed coding scheme for a longitudinal study in which we follow students from general chemistry through…

A laboratory experiment is detailed that entails the separation and derivatization of the artificial sweetener sucralose from a commercially available sweetener mixture. The experiment utilizes 1 g packets of a sucralose-based artificial sweetener and involves the separation of the synthetic sweetener from the more polar bulk additives by…

A reliable method for bleach-based alcohol oxidation has been developed. Use of sodium bisulfate as the acid additive in the reaction mixture eliminates the various problems associated with acetic acid, which has commonly been used for this type of oxidation. By conducting the reaction in an ethyl acetate/water two-phase reaction mixture,…

A physical model has been designed to help students visualize concepts involved when solving infrared spectra. The physical model uses balls and springs to incorporate the harmonic oscillator model and Hooke's law to study dynamic vibrations within diatomic molecules. Various concepts are addressed with the model to abstract principles about how…