Essential oils serve as a valuable, inexpensive natural supply of useful organic compounds that possess various biological activities, including antimicrobial properties, and most oils emit pleasant and familiar odors. They are an excellent source of analytes for introductory organic laboratory experiments. We report an experiment in which…

Appealing to students' affect in academic settings, such as demonstrating chemistry's relevance to their life, is one strategy instructors may use to support students' in learning. This study investigates the types of connections that students make to organic chemistry when responding to an open-ended writing assignment. Students enrolled in an…

A multicomponent reaction was adapted and successfully applied in the major organic course, which involves synthesizing and characterizing a 1,3-benzoxazine derived from paracetamol extracted from tablets of the worldwide well-known medicine Tylenol. Using paracetamol as a reagent is a motivational strategy in undergraduate laboratories to meet…

Despite representations' central role in conveying chemical phenomena, mastering them is not trivial, given the wide variety of different conventions to interpret and use them. Furthermore, instructional approaches and materials may overlook explicit discussion on how students should reason with representations. To gather evidence that could guide…

This study seeks to elucidate the fundamental principles underlying the hydration, hydrolysis, and enolization of [beta]-diketones, aiming to enhance students' comprehension of the link between fundamental chemical principles and the practical implications of keto-enol tautomerization and diketone-gem diol equilibrium in diverse chemical…

Electrophilic aromatic substitution (S[subscript E]Ar) and nucleophilic aromatic substitution (S[subscript N]Ar) reactions are among the most valuable reactions in the conversion of aromatic rings. While these reactions are typically covered in separate experiments in undergraduate organic courses, a continuous experimental setup elucidating both…

Despite the important role organic chemistry plays in a wide range of industries, the undergraduate organic chemistry course sequence is considered to be difficult for and feared by students. Although work has been done to identify and address student difficulties within the cognitive and psychomotor domains, little work has focused on…

Organic chemistry is accepted as a crucial part of science higher education funneling students into many career opportunities such as pharmaceuticals, biotechnology, and medical industries. Students attempting organic chemistry courses in higher education are among a plethora of majors including biology, chemistry, health science, and engineering.…

High-resolution mass spectrometry (HRMS) is an analytical technique that is typically used by mass spectrometry experts. However, with recent advancements, it is becoming more accessible to students in organic chemistry laboratories. Still, a significant knowledge gap exists between these experts and students. A straightforward laboratory…

The imine condensation reaction is commonly addressed in second semester organic chemistry classrooms as imines and their derivatives are found in many pharmaceutical scaffolds and biological and catalytic processes. Despite this, imine condensations are still absent from many organic chemistry laboratory curriculums. The work discussed here…

Practice examinations developed at the ACS Examinations Institute ask students to self-report mental effort when answering items. This self-reported mental effort together with performance can be represented in the form of a cognitive efficiency graph for each student giving information on the utilization of cognitive resources and content…

Applying the idea of green chemistry, we extended an esterification teaching experiment with isoamyl alcohol and acetic acid and reused isoamyl acetate in the transesterification reaction with KOH as the catalyst. As a result, isoamyl alcohol was produced and could be reused for the teaching experiment. The simplified experimental method achieved…

Valid rubrics facilitate assessing the level of complexity in students' open-ended responses. To design a valid rubric, it is essential to thoroughly define the types of responses that represent evidence of varying complexity levels. Formulating such evidence statements can be approached deductively by adopting predefined criteria from the…

A comprehensive teaching experiment plan tailored forthird-yearundergraduates has been developed. Initially, instructors synthesize(E)-2-(4-((4-(2-hydroxyethoxy)-3-methylphenyl)­diazenyl)­phenoxy)-ethan-1-ol­(M-Azo-2)monomer as part of the preclass preparation. Subsequently, studentsperform an acylation reaction experiment to prepare an…

Chemical reactions that mimic the function of ATP hydrolysis in biochemistry are of current interest in nonequilibrium systems chemistry. The formation of transient bonds from these reactions can drive molecular machines or generate materials with time-dependent properties. While the behavior of these systems can be complicated, the underlying…