The author's organic chemistry course at Thomas Jefferson University incorporated student engagement activities through Nearpod, a web-based classroom response system. After transitioning to remote instruction due to the COVID-19 outbreak in the spring of 2020, students were given the option to complete multiple-choice poll questions either…

During the transition from an in-person Organic Chemistry II class to a remote learning version of the class midsemester, a small-group problem-solving session exercise was replaced with embedded video questions as a low-stakes assignment with direct instructor feedback. Whereas the in-person small-group problem-solving session was a group…

Given student familiarity with electronic cigarettes (e-cigs), this lab uses a student-built smoke collection apparatus to collect e-cig vapors to teach students about gas chromatography-mass spectrometry (GC-MS). Students in a second semester, introductory organic chemistry course spent 1 week collecting e-cig vapors and 1 week qualitatively…

Embodied learning tools (ELTs), such as building and manipulating models, bolster students' learning of spatially demanding science content, such as stereochemistry. However, studies comparing the effectiveness of virtual to physical ELTs on student learning are limited. This study compares online instruction using a virtual ELT, virtual models,…

A two-week summer camp was designed, implemented, and then updated for high school students focusing on organic chemistry, solar energy, and green chemistry principles. Students learn about laboratory safety, perform organic reactions, go on field trips, and take part in interactive lessons that focus on both fundamental chemistry topics as well…

We present here an extension of Morrison's and Ruder's "Sequence-Response Questions" (SRQs) that allows for more nuance in the assessment of student responses to these questions. We have implemented grading software (which we call ANGST, "Automated Nuanced Grading & Statistics Tool") in a Microsoft Excel sheet that can take…

A multifaceted experiment, accessible to students either in an introductory organic chemistry course or in a more advanced laboratory setting, is described for investigating the addition of dichlorocarbene to E- and Z-[beta]-methylstyrenes. The innovative exercise, which integrates elements of synthesis, mechanisms, instrumental analysis,…

An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as part of the Distributed Drug Discovery (D3) program. Students use solid-phase synthesis techniques to complete a three-step, combinatorial synthesis of six products, which are analyzed using LC-MS and NMR spectroscopy. This protocol is suitable for…

The Suzuki-Miyaura cross-coupling reaction, which is one of the most important methods for C-C bond formation in modern organic synthesis, exhibits broad functional group compatibility. A Suzuki-Miyaura cross-coupling protocol is reported that is suitable for demonstrating this compatibility in undergraduate laboratories. In this reaction, two…

The synthesis of substituted 1,4-benzoquinones, a biologically important class of compounds, was developed using [mu]-oxodi(phenyliodanyl) diacetate, a (diacetoxyiodo)benzene-based oxidizing reagent, in order to introduce second-year undergraduate organic laboratory students in their second semester or advanced organic students to increasingly…

In recent years, researchers have worked diligently to identify more effective means of facilitating student learning. Some promising pedagogical techniques that have emerged include the flipped-class model and test-enhanced learning. These pedagogical strategies have been incorporated into a multitouch book. A multitouch book is a dynamic…

The content and design scheme for a readily adaptable, research-based laboratory course in chemical biology are presented. In this course, students interrogate protein structure and function using the site-specific incorporation of noncanonical amino acids by genetic code expansion. The relatively new field of genetic code expansion enables…

This quantitative study examines the impact of a three-week online organic preparatory course for chemistry undergraduates that is designed to improve student performance in the subsequent organic chemistry course series (N = 1,289). Organic chemistry often serves as a gatekeeper for students pursuing careers in science, technology, engineering,…

Representational competence (RC) is a set of skills to reflectively use a variety of representations to draw inferences, make predictions, and support claims. Despite the important role RC plays in student success in chemistry and the considerable number of investigations into student ability to reason with representations, little is known about…

Large introductory STEM courses have a reputation as "weed out" classes. These classes and their laboratory components are more often viewed by students as hurdles to overcome than valuable learning experiences relevant to their future careers. This perception especially impacts students who have a lower science identity and…