People with disabilities develop skills associated with self-determined action when supports and opportunities, aligned to their strengths and values, are provided in the environments in which they live, learn, and work. Researchers have suggested that a complex array of contextual factors impacts how people with disabilities and their key…

In the era of the "reproducibility crisis" and the "P-value controversy" new ways of presentation and interpretation of the results of a meta-analysis are desirable. One suggestion that has been made for single studies almost six decades ago and taken up now and then is the P-value function. For a given outcome, this function…

Introduction: Interrupted Time Series (ITS) studies may be used to assess the impact of an interruption, such as an intervention or exposure. The data from such studies are particularly amenable to visual display and, when clearly depicted, can readily show the short- and long-term impact of an interruption. Further, well-constructed graphs allow…

Diagnostic test accuracy (DTA) systematic reviews are conducted to summarize evidence on the accuracy of a diagnostic test including a critical evaluation of the primary studies. Where appropriate, the evidence is meta-analyzed to obtain pooled estimates of effectiveness. In this study, we reviewed and critiqued three DTA guidance documents with…

Statistical methods are increasingly being used to integrate findings from the ever-expanding universe of empirical research. Meta-analysis encompasses various techniques for synthesizing summary statistics, and mega-analysis pools raw data across studies. This paper offers an introduction to meta-analysis and mega-analysis that complements the…

Systematic reviews with meta-analyses are powerful tools that can answer research questions based on data from published studies. Ideally, all relevant data is directly available in the text or tables, but often it is only presented in graphs. In those cases, the data can be extracted from graphs, but this potentially introduces errors. Here, we…

Network meta-analysis (NMA) is a statistical technique for the comparison of treatment options. Outcomes of Bayesian NMA include estimates of treatment effects, and the probabilities that each treatment is ranked best, second best and so on. How exactly network topology affects the accuracy and precision of these outcomes is not fully understood.…

Methods for indirect comparisons and network meta-analysis use aggregate level data from multiple studies. A very common, and closely related, scenario is where a company has individual patient data (IPD) from its own trial, but only has published aggregate data from a competitor's trial, and an indirect comparison of the treatments evaluated in…

Content-based techniques for credibility assessment (Criteria-Based Content Analysis [CBCA], Reality Monitoring [RM]) have been shown to distinguish between experience-based and fabricated statements in previous meta-analyses. New simulations raised the question whether these results are reliable revealing that using meta-analytic methods on…

A reference interval provides a basis for physicians to determine whether a measurement is typical of a healthy individual. It can be interpreted as a prediction interval for a new individual from the overall population. However, a reference interval based on a single study may not be representative of the broader population. Meta-analysis can…

Background: Undergraduate STEM instructors want to help students learn and retain knowledge for their future courses and careers. One promising evidence-based technique that is thought to increase long-term memory is spaced retrieval practice, or repeated testing over time. The beneficial effect of spacing has repeatedly been demonstrated in the…

Drug repurposing refers to the process of discovering new therapeutic uses for existing medicines. Compared to traditional drug discovery, drug repurposing is attractive for its speed, cost, and reduced risk of failure. However, existing approaches for drug repurposing involve complex, computationally-intensive analytical methods that are not…

The United States Chairman of the Joint Chiefs of Staff declared critical thinking as a capability imperative for Force XXI. He directed Military Services to develop critical thinkers. There is limited evidence of success in terms of developing critical thinking abilities. Specifically, the U.S. Army lacks a single, generally accepted, codified…

As the COVID-19 pandemic fades into the background, higher education institutions think about what they can learn from the vast shift to online teaching and learning--the recent period emphasized the significance of autonomous learning abilities, as students who were skilled in self-regulation were able to cope with the challenges of remote…

Individual participant data (IPD) meta-analysis projects obtain, harmonise, and synthesise original data from multiple studies. Many IPD meta-analyses of randomised trials are initiated to identify treatment effect modifiers at the individual level, thus requiring statistical modelling of interactions between treatment effect and participant-level…