Objective: This study explored the relations between campus safety and loneliness among Asian and Asian American college students. We investigated the mediation effect of psychological distress and the moderation effect of COVID-19-related discrimination in these relations. Participants: 1,685 Asian and Asian American college students who participated in the Fall 2020, American College Health Association -- National College Health Assessment III survey. Method: The moderated mediation analysis was conducted. Results: The findings revealed a negative correlation between campus safety and both psychological distress (b = -0.05, p < 0.001) and loneliness (b = -0.12, p < 0.001), but this weakened for those experiencing COVID-19 discrimination. Psychological distress consistently mediated the safety-loneliness link regardless of discrimination. Conclusions: The current findings highlight the support from the university for Asian and Asian American college students. The specific implications for practice and policy are discussed.