The medial temporal lobe (MTL), including the hippocampus (HC), perirhinal cortex (PRC), and parahippocampal cortex (PHC), is central to memory formation. Reward enhances memory through interplay between the HC and substantia nigra/ventral tegmental area (SNVTA). While the SNVTA also innervates the MTL cortex and amygdala (AMY), their role in…

The ubiquitin proteasome system (UPS) is a primary mechanism through which proteins are degraded in cells. UPS activity in the dorsal hippocampus (DH) is necessary for multiple types of memory, including object memory, in male rodents. However, sex differences in DH UPS activation after fear conditioning suggest that other forms of learning may…

A critical role of protein modifications such as phosphorylation and acetylation in synaptic plasticity and memory is well documented. Tyrosine sulfation plays important roles in several biological processes. However, its role in synaptic plasticity and memory is not well understood. Here, we show that sulfation contributes to long-term…

During language comprehension, the brain typically converts a stream of sensory input into meaningful mental representations. But not all of the information the brain needs or uses is physically available in the language signal it encounters: the brain often anticipates and processes some information before it becomes available, and it often also…

Language learning is influenced by both neural development and environmental experiences. This work investigates the influence of early bilingual experience on the neural mechanisms underlying speech processing in 4-month-old infants. We study how an early environmental factor such as bilingualism interacts with neural development by comparing…

Autism Spectrum Disorder (ASD) is a heterogeneous condition associated with differences in functional neural connectivity relative to neurotypical (NT) peers. Language-based functional connectivity represents an ideal context in which to characterize connectivity because language is heterogeneous and linked to core features in ASD, and NT language…

Symbolic numeracy first emerges as children learn the meanings of number words and how to use them to precisely count sets of objects. This development starts before children enter school and forms a foundation for lifelong mathematics achievement. Despite its importance, exactly how children acquire this basic knowledge is unclear. Here we test…

Exercise intervention has been proven helpful to ameliorate core symptoms of Autism Spectrum Disorder (ASD). However, the underlying mechanisms are not fully understood. In this study, we carried out a 12-week mini-basketball training program (MBTP) on ASD children and examined the changes of brain functional and structural networks before and…

Successful language comprehension requires the rapid deployment of working memory resources alongside the capacity to predict upcoming linguistic input. While previous research views these as competing factors, this dissertation explores a unified theory of processing complexity and evaluates the interaction between memory and prediction. The…

Observational practice is discussed as a substitute for physical practice for motor learning and adaptation. We systematically reviewed the literature on observational practice in reaching and aiming tasks. Our objectives were to identify (i) performance differences between observational and physical practice; (ii) factors that contribute to…

Reading is a complex, uniquely human invention for communication through print. It is a critical ability for making progress in education. Students with reading difficulties, the most common learning disability, struggle with reading fluency and accuracy. Skilled reading is enabled by the coordination of a network of brain regions interconnected…

Studies have found that flipped classroom teaching (FT) improves learning compared to lecture-based teaching (LT). However, whether the structured teacher-student interaction--the key feature of FT--plays an essential role in enhancing learning remains unclear, as do its neural underpinnings. Here, we compared three teaching conditions: FT with a…

Novelty seeking has been found to affect creative performance, but its impact on the temporal dynamics of creative information processing remains unclear. Creative information is identified by two key indicators--novelty and appropriateness. To explore the effect of novelty seeking on the temporal processing of novelty and appropriateness, a…

The existing performance evaluation methods in robot-assisted surgery (RAS) are mainly subjective, costly, and affected by shortcomings such as the inconsistency of results and dependency on the raters' opinions. The aim of this study was to develop models for an objective evaluation of performance and rate of learning RAS skills while practicing…

We evaluate the effectiveness of reading aloud a program code in learning programming from a neuroscientific perspective by measuring brain activity using a near-infrared spectroscopy device. The results show that when reading aloud and then reading silently, brain activity increases during reading aloud; a similar trend is observed when the…