Reproduction health did not mean absence of interference in reproduction functions and systems, but rather wider than that. This research aimed to compared the effects of the implementation of parenting models and conventional models toward the knowledge of reproduction health of SMK students. It was a quasi experiment research with pre-test post-test nonequivalent control group design. The population of research was the students of SMK Muhammadiyah 6 Lebong, Bengkulu, Indonesia. The sample of this research was taken by using cluster random sampling technique. The research instrument was a reproduction health knowledge test. The data was analyzed by using ANOVA. The results showed that the implementation of parenting model had the highest score and was significantly different from the scores of conventional models. Thus, the conclusion of this research had a significant effect on the enhancement of reproduction health knowledge of high school students.