Researchers, practitioners, and policymakers have increasingly emphasized the importance of a proactive, multidisciplinary approach to human trafficking that involves all systems responsible for protecting youth, including K-12 schools. Several states have passed mandates requiring students and/or educators and school staff to receive human trafficking prevention education, while schools and districts in other states have decided to deliver this programming on their own. However, limited research exists on how to best equip students, educators, and other school staff to prevent human trafficking and how schools can respond to human trafficking concerns. This brief describes some key considerations for educators, school staff, and school and district leaders who are interested in delivering human trafficking prevention education activities in their schools.