The dopaminergic modulation of long-term potentiation (LTP) has been studied well, but the mechanism by which dopamine induces LTP (DA-LTP) in CA1 pyramidal neurons is unknown. Here, we report that DA-LTP in basal dendrites is dependent while in apical dendrites it is independent of activation of L-type voltage-gated calcium channels (VDCC).…

The growing consensus that language is distributed into large-scale cortical and subcortical networks has brought with it an increasing focus on the connectional anatomy of language, or how particular fibre pathways connect regions within the language network. Understanding connectivity of the language network could provide critical insights into…

The neural correlates of cognitive control for typically developing 9-year-old children were examined using dense-array ERPs and estimates of cortical activation (LORETA) during a go/no-go task with two conditions: a neutral picture condition and an affectively charged picture condition. Activation was estimated for the entire cortex after which…

Poverty-associated chronic stress is a serious threat not only to a mother's mental health but also to maternal functioning. Recent neuroimaging studies suggest that a mother's brain undergoes dynamic changes to support her transition to parenthood, including better emotion regulation and heightened sensitivity to infants. However, we propose that…

Psycholinguistic research spanning a number of decades has produced diverging results with regard to the nature of constraint integration in online sentence processing. For example, evidence that language users anticipatorily fixate likely upcoming referents in advance of evidence in the speech signal supports rapid context integration. By…

Observable behavior, such as test scores, is the gold standard by which we make judgments about levels of function, grade placements, and the presence/absence of pathology. Individual differences in test performance have long intrigued researchers and clinicians, and some have noted how people can come up with essentially the same answers using…

The SERIOL model of orthographic analysis proposed mechanisms for converting visual input into a serial encoding of letter order, which involved hemisphere-specific processing at the retinotopic level. As a test of SERIOL predictions, we conducted a consonant trigram-identification experiment, where the trigrams were briefly presented at various…

Previous behavioral studies have shown that individuals with autism are less hindered by interference from global processing during the performance of lower-level perceptual tasks, such as finding embedded figures. The primary goal of this study was to examine the brain manifestation of such atypicality in high-functioning autism using fMRI.…

The two members of the Staufen family of RNA-binding proteins, Stau1 and Stau2, are present in distinct ribonucleoprotein complexes and associate with different mRNAs. Stau1 is required for protein synthesis-dependent long-term potentiation (L-LTP) in hippocampal pyramidal cells. However, the role of Stau2 in synaptic plasticity remains…

Working memory is the limited capacity storage system involved in the maintenance and manipulation of information over short periods of time. Previous imaging studies have suggested that the frontoparietal regions are activated during working memory tasks; a putative association between the structure of the frontoparietal regions and working…

Using functional magnetic resonance imaging (fMRI), this study investigates and discusses neurological explanations for, and the educational implications of, the neural network activations involved in hypothesis-generating and hypothesis-understanding for biology education. Two sets of task paradigms about biological phenomena were designed:…

In daily communication, we often use indirect speech to convey our intention. However, little is known about the brain mechanisms that underlie the comprehension of indirect speech. In this study, we conducted a functional MRI experiment using a scenario reading task to compare the neural activity induced by an indirect reply (a type of indirect…

Efficient reading relies on expertise in the visual word form area, with abnormalities in the functional specialization of this area observed in individuals with developmental dyslexia. We have investigated event related potentials in print tuning in adults with dyslexia, based on their N170 response at 135-255 ms. Control and dyslexic adults…

This study used fMRI to measure brain activity during adult processing of cries of infants with autistic disorder (AD) compared to cries of typically developing (TD) infants. Using whole brain analysis, we found that cries of infants with AD compared to those of TD infants elicited enhanced activity in brain regions associated with verbal and…

Cortical regions supporting cognitive control and memory judgment are structurally immature in adolescents. Here we studied adolescents (13-15 y.o.) and young adults (20-22 y.o.) using a recognition memory paradigm that modulates cognitive control demands through cues that probabilistically forecast memory probe status. Behaviorally, adolescence…