Background: Asthma and respiratory diseases pose significant global health risks. Respiratory infections substantially impact individuals with Down syndrome, affecting their overall well-being. This study examines respiratory health risks associated with Down syndrome in Saudi Arabia. Method: A survey of 115 participants used convenience sampling to assess chronic respiratory disease incidence. Caregivers provided insights for cross-sectional analysis, with chi-square tests for categorical variables and Kendall's Tau for binary relationships. Hypothesis testing was done at a 5% significance level. Results: There was a significant increase in respiratory infections among people with Down syndrome in Saudi Arabia. Most participants (53%) reported chest pain, followed by wheezing in 47.8%. There was a need for interventions to be targeted by region, resulting in improved health outcomes. Conclusions: Individuals who have Down syndrome in Saudi Arabia necessitate a gateway to healthcare, public health education and customised therapies.