Apurinic/apyrimidinic (AP or abasic) sites are deoxyribonucleic acid (DNA) lesions that result from the loss of a nucleobase by hydrolysis of the "N"-glycosyl bond. AP sites are the most frequent lesions in cells and are caused by environmental and cancer therapeutic genotoxins. Herein, the bicinchoninic colorimetric assay, typically…

In 1900, three botanists claimed they had found regularities in inheritance, which soon would be known as Mendel's Laws, without knowing the work of Gregor Mendel or of each other. Their claims of independent (re)discovery have been thoroughly studied during the past decades, with various outcomes. The case is still of interest today as it offers…

Twins regularly score nearly a standard deviation below the population mean on standardized measures of cognitive development in infancy but recover to the population mean by early childhood, making rapid gains through the toddler years. To date, only polynomial growth models have been fit to model cognitive recovery across childhood, limiting the…

The purpose of the study was to characterize repetitive phenomena in Williams syndrome (WS). The parents of 60 subjects with WS completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) or Children's Y-BOCS, the Yale Global Tic Severity Scale, the Stereotyped Behavior Scale, and the Spence Children's Anxiety Scale--Parent Version. Nineteen…

Our institution developed and continuously improved a Neurodevelopmental Reflex (NDR) algorithm to help physicians with genetic test ordering for neurodevelopmental disorders (NDDs). To assess its performance, we performed a retrospective study of 511 patients tested through NDR from 2018 to 2019. SNP Microarray identified pathogenic/likely…

Extensive research has established that fathers' engagement in parenting benefits children, but few studies have described how fathers contribute to child development even before birth. In this article, we consider both direct and indirect pathways through which expectant fathers shape child development during the prenatal period. Regarding direct…

Investigations into the etiology of autism spectrum disorders have been largely confined to two realms: variations in DNA sequence and somatic developmental exposures. Here we suggest a third route--disruption of the germline epigenome induced by exogenous toxicants during a parent's gamete development. Similar to cases of germline mutation, these…

Genetic, neurobiological, neurochemical, environmental factors and their interactions contribute to autism phenotypes. Blood from 48 (age range: 4-17) autism spectrum disorder diagnosed patients (ASD) and 38 age- and gender-matched healthy control subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, albumin, serum…

Polygenic scores for educational attainment and related variables, such as IQ and "mathematical ability" are now readily available via direct-to-consumer genetic testing companies. Some researchers are even proposing the use of genetic tests in educational settings via "precision education," in which individualized student…

Across a wide range of studies, researchers often conclude that the home environment and children's outcomes are causally linked. In contrast, behavioral genetic studies show that parents influence their children by providing them with both environment and genes, meaning the environment that parents provide should not be considered in the absence…

In recent years, modern technologies have enabled the collection of exponentially larger quantities of data in the biomedical domain and elsewhere. In particular, the advent of single-cell genomics has allowed for the collection of datasets containing hundreds of thousands of cells measured in tens of thousands of dimensions. This rapid expansion…

Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a…

Hormones are the major signaling molecules that have a complex signaling cascade involving intracellular and intranuclear receptors, coreceptors, and signal transduction pathways. The molecular mechanism of hormonal action is written in a poetic verse to kindle the interest of students and to augment their affinity toward the onerous yet awesome…

Birth weight is a robust predictor of valued life course outcomes, emphasizing the importance of prenatal development. But does birth weight act as a proxy for environmental conditions in utero, or do biological processes surrounding birth weight themselves play a role in healthy development? To answer this question, we leverage variation in birth…

The study examines the role of independent work in enhancing the genetic knowledge of third-year biology students within a multilingual education setting. Conducted at Abai Kazakh National Pedagogical University, the research involved 164 biology teacher candidates. A quasi-experimental design with pre-test and post-test measures was employed to…