Task-cueing studies suggest that the updating of sensory and task representations both contribute to behavioral task-switch costs [Forstmann, B. U., Brass, M., & Koch, I. (2007). "Methodological and empirical issues when dissociating cue-related from task-related processes in the explicit task-cuing procedure." "Psychological Research, 71"(4),…

Theory of mind requires an understanding of both desires and beliefs. Moreover, children understand desires before beliefs. Little is known about the mechanisms underlying this developmental lag. Additionally, previous neuroimaging and neurophysiological studies have neglected the direct comparison of these developmentally critical mental-state…

Segmentation of target odorants from background odorants is a fundamental computational requirement for the olfactory system and is thought to be behaviorally mediated by olfactory habituation memory. Data from our laboratory have shown that odor-specific adaptation in piriform neurons, mediated at least partially by synaptic adaptation between…

Cerebellar malformations are increasingly diagnosed in the fetal period. Consequently, their consideration requires stressful and often critical decisions from both clinicians and families. This has resulted in an emergent need to understand better the impact of these early life lesions on child development. We performed a comprehensive literature…

Functional transcranial Doppler ultrasound (fTCD) is a relatively new and non-invasive technique that assesses cerebral lateralisation through measurements of blood flow velocity in the middle cerebral arteries. In this study fTCD was used to compare functional asymmetry during a word generation task between a group of 30 dyslexic adults and a…

Two chronic, nonfluent aphasia patients participated in overt naming fMRI scans, pre- and post-a series of repetitive transcranial magnetic stimulation (rTMS) treatments as part of a TMS study to improve naming. Each patient received 10, 1-Hz rTMS treatments to suppress a part of R pars triangularis. P1 was a "good responder" with improved naming…

Early studies reported preserved formulaic language in left hemisphere damaged subjects and reduced incidence of formulaic expressions in the conversational speech of stroke patients with right hemispheric damage. Clinical observations suggest a possible role also of subcortical nuclei. This study examined formulaic language in the spontaneous…

This study investigated the production of linguistic prosody in subjects with left hemisphere damage (LHD). Three experiments involving the production of lexical stress in nouns vs verbs, compound nouns vs tag constructions, and echo questions vs statements were conducted. Acoustic measurements (fundamental frequency (F[subscript 0]), duration and…

This study explored proximal-to-distal components during goal-directed reaching movements in children with mild or moderate hemiplegic cerebral palsy (HCP); [seven females, four males; mean age 8y 6mo; SD 27mo], compared with age-matched, typically developing children (seven females, five males; mean age 8y 3mo [SD 25mo]. Severity of HCP was…

Neural activity associated with self-referential processing of emotional stimuli was investigated using whole brain functional magnetic resonance imaging (fMRI). Fifteen healthy subjects underwent fMRI scanning while making judgments about positive and negative trait words in four conditions (self-reference, other-reference, semantic processing,…

With the advancement of image acquisition and analysis methods in recent decades, unique opportunities have emerged to study the neuroanatomical correlates of intelligence. Traditional approaches examining global measures have been complemented by insights from more regional analyses based on pre-defined areas. Newer state-of-the-art approaches…

Throughout history, vestibular and emotional dysregulation have often manifested together in clinical settings, with little consideration that they may have a common basis. Regarding vestibular mechanisms, the role of brainstem and cerebellar structures has been emphasized in the neurological literature, whereas emotion processing in the cerebral…

New granule cells are born throughout life in the dentate gyrus of the hippocampal formation. Given the fundamental role of the hippocampus in processes underlying certain forms of learning and memory, it has been speculated that newborn granule cells contribute to cognition. However, previous strategies aiming to causally link newborn neurons…

Rough-and-tumble play, or play fighting, is common in the young of many mammals. Research on play fighting among rats shows that there are many levels of neural control over this behavior: subcortical mechanisms mediate the motivation and behavior of such play, and the cortex provides mechanisms by which the play changes with age and context. The…

Jaak Panksepp, known best for his work on animal emotions and coining the term "affective neuroscience," investigates the primary processes of brain and mind that enable and drive emotion. As an undergraduate, he briefly considered a career in electrical engineering but turned instead to psychology, which led to a 1969 University of…