Formation of eukaryotic initiation factor 4F (eIF4F) is widely considered to be the rate-limiting step in cap-dependent translation initiation. Components of eIF4F are often up-regulated in various cancers, and much work has been done to elucidate the role of each of the translation initiation factors in cancer cell growth and survival. In fact,…

We identify and discuss the phenomenon of narrative stability, in the context of current methodological literature on interviewing. It derives from two independent studies, undertaken fifteen years apart, of members of the same genetics research group who were interviewed by different researchers. The first ('Discovery') interviews were collected…

Students tend to think of their science courses as isolated and unrelated to each other, making it difficult for them to see connections across disciplines. In addition, many existing science assessments target rote memorization and algorithmic problem-solving skills. Here, we describe the development, implementation, and evaluation of an activity…

Laboratory practical sessions are critical to scientific training in biology but usually fail to promote logical and hypothesis-driven reasoning and rely heavily on the teacher's instructions. This paper describes a 2-day laboratory practicum in which students prepare and analyze larval cuticle preparations of "Drosophila" segmentation…

Children with Coloboma, Heart defects, Atresia choanae, Restricted growth, Genital hypoplasia, and Ear abnormalities (CHARGE) syndrome have many sensory impairments that can cause delays in motor development impacting physical activity, health, and quality of life. However, only one limited study has investigated motor competence in children with…

Episodic future thinking (EFT) has been suggested to underlie anticipatory pleasure (AP), itself known to play a crucial role in social functioning (SF). Both AP and SF are impaired in various clinical populations, including autism spectrum disorders (ASD) and 22q11.2 deletion syndrome (22q11DS). Therefore, the relationship between EFT, AP and SF…

What it means to be human is inherently incomplete or in a state of permanent mutability. This is excellent for it opens the way to the questions of the inhuman, posthuman, and nonhuman to take center stage in the analysis of what it means to be a subject, which is a core question for education. The question of the inhuman at the core of the human…

Ever since the birth of the first baby born through in vitro fertilization in 1978, advances in reproductive technologies have raised new concerns about the outcomes for children. In this article, I summarize research on children born through assisted reproduction involving a third party, that is, children born through egg donation, sperm…

We further extended the use of a microswitch-cluster technology to promote object manipulation and to reduce tongue protrusion in seven children with Angelman syndrome. Study I included seven participants with severe to profound developmental disabilities. An ABB[superscript 1]AB[superscript 1] experimental sequence was implemented. During the…

Children with autism have a significantly lower quality of life compared with their neurotypical peers. While multiple studies have quantified the impact of autism on health-related quality of life (HRQoL) through standardized surveys such as the PedsQL, none have specifically investigated the impact of syndromic autism. Here we evaluate HRQoL in…

Teaching and learning approaches in the college classroom can be enhanced beyond the traditional lecture by using technological tools and research-based instructional techniques. In particular, instructional technology can allow large numbers of students to engage with content, instructors, and each other in a meaningful learning process.…

This paper explores the first-hand accounts of disablist school violence experienced by young people with dwarfism during their secondary education in the United Kingdom. A narrative, qualitative methodology was utilised, which turned nineteen young people with dwarfism into the storytellers of their schooling experiences. Drawing together a…

Movement and mobility are a significant aspect of early childhood. Assistive technology and adapted mobility can be a critical aspect of the early intervention process by promoting access to play, the environment, social opportunities, and development of visual perceptual and navigational skills. This case study describes the design, materials,…

The relationship between sensory processing and ASD-like and associated behaviors in patients with Prader-Willi Syndrome (PWS) remains relatively unexplored. Examining this relationship, 51 adults with PWS were administered the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS), Short Sensory Profile (SSP-J), Food-Related…

Inclusion of male and female subjects in behavioral neuroscience research requires a concerted effort to characterize sex differences in standardized behavioral assays. Sex differences in hippocampus-dependent assays have been widely reported but are still poorly characterized. In the present study, we conducted a parametric analysis of…