The theory of evolution is the central combing theory that brings together all the tenets of biology that bring about a solid understanding of life. It is also one of the most controversial scientific theories of all time and is widely rejected by about 40% of the general public in the United States. One of the biggest reasons for low evolution…

Dendritic regulatory BC1 RNA is a non-protein-coding (npc) RNA that operates in the translational control of gene expression. The absence of BC1 RNA in BC1 knockout (KO) animals causes translational dysregulation that entails neuronal phenotypic alterations including prolonged epileptiform discharges, audiogenic seizure activity in vivo, and…

We characterized the transcriptional response accompanying maintenance of long-term sensitization (LTS) memory in the pleural ganglia of "Aplysia californica" using microarray (N = 8) and qPCR (N = 11 additional samples). We found that 24 h after memory induction there is strong regulation of 1198 transcripts (748 up and 450 down) in a…

Children with attention deficit hyperactivity disorder (ADHD) often experience co-occurring emotional problems. ADHD with this comorbidity is associated with poorer outcomes than ADHD without comorbidity. Better understanding of the etiology of comorbidity could improve prevention of negative outcomes for children with ADHD. The sample consisted…

Next Generation Sequencing (NGS) has become an important tool in the biological sciences and has a growing number of applications across medical fields. Currently, few undergraduate programs provide training in the design and implementation of NGS applications. Here, we describe an inquiry-based laboratory exercise for a college-level molecular…

Consideration of socioscientific issues (SSIs) promotes the development of moral and sociocultural perspectives that encourage a rich understanding of the nature of science. The use of moral reasoning to approach SSIs is known to influence how students justify arguments and persuade others; less is known about how student moral reasoning is…

Background: There is a need to systematically compare and contrast mortality predictors and disparities in people with intellectual disabilities (ID) for global prevention strategy development. Method: Bibliographic databases and grey literature were searched using systematic review methodology and the machine learning tool "Abstrackr."…

This study investigates the factors driving football players with identical training experience and genetics to have dramatically different career paths. We studied two paired cases from a pool of 32 talented U-20 players who were twice World Champions. The first paired case is a set of monozygotic twins that played football for exactly the same…

Spinal Muscular Atrophy is a genetic, degenerative disorder, in which individuals become unable to engage in typical motor activities, including speech. The outcome for the most common type of SMA (Type 1), has previously been death before the age of 2, but new medical improvements are showing promising results for life longevity. Research has…

Most long-term memories are forgotten. What happens, then, to the changes in neuronal gene expression that were initially required to encode and maintain the memory? Here we show that the decay of recall for long-term sensitization memory in "Aplysia" is accompanied both by a form of savings memory (easier relearning) and by persistent…

The Hardy-Weinberg principle (HWP) is a fundamental model upon which much of the discipline of population genetics is based. Despite its significance, students often leave introductory biology courses with only a shallow understanding of the use and implications of the HWP. I contend that this deficiency in student comprehension is too-often a…

The teaching of quantitative genetic variation in the undergraduate laboratory practical environment can be difficult as, for quantitative phenotypes that are under the control of multiple loci, detection of phenotypic differences caused by individual variants is problematical without large samples, impractical in such classes. Pet dogs provide a…

Two-dimensional nuclear magnetic resonance (2D NMR) techniques are regularly used for the determination of RNA structures. In an effort to introduce advanced level students who are generally not acquainted with or exposed to these techniques, this work, which has been designed as a practicum, utilizes a combination of 2D NMR techniques to help…

Basic quantitative and population genetics topics are typically taught in introductory plant breeding courses and are critical for success in upper-level study. Active learning, including simulations and games, may be useful for instruction of these concepts, which rely heavily on theory and may be more challenging for students. The statistical…

We examined the sophistication of middle school students' mechanistic explanations of genetics phenomena and how they interact with a technology-based explanation tool as they articulate and organize their ideas about the phenomena. We coordinated curriculum and assessment design frameworks to develop a middle school curriculum unit that engages…