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Smith, Michaele R.; Hildenbrand, Hanna; Smith, Ann C. M. – Physical & Occupational Therapy in Pediatrics, 2009
Smith-Magenis syndrome (SMS), the result of an interstitial deletion within chromosome 17p11.2, is a disorder that may include minor dysmorphic features, brachydactyly, short stature, hypotonia, speech delays, cognitive deficits, signs of peripheral neuropathy, scoliosis, and neurobehavioral problems including sleep disturbances and maladaptive…
Descriptors: Twins, Females, Genetic Disorders, Physical Therapy
Goodsell, David S. – Biochemistry and Molecular Biology Education, 2009
Diverse biological data may be used to create illustrations of molecules in their cellular context. I describe the scientific results that support a recent textbook illustration of an "Escherichia coli cell". The image magnifies a portion of the bacterium at one million times, showing the location and form of individual macromolecules. Results…
Descriptors: Biology, Biochemistry, Molecular Structure, Science Instruction
Greenwald, Brian H. – Sign Language Studies, 2009
Historian Brian Greenwald offers a revisionist interpretation of Bell. He reviews Bell's role and influence within the American eugenics movement and shows that Bell had the respect of the most prominent American eugenicists. His intimate knowledge of deafness, from personal experience with his mother and wife and from his studies of deaf people…
Descriptors: United States History, Time Perspective, Genetics, Improvement
Carvey, Jayme S.; Bernhardt, B. May – Child Language Teaching and Therapy, 2009
Rubinstein-Taybi syndrome (RTS) is a rare genetic developmental disorder that often shows associated language delay. However, literature on language development in RTS is very limited, particularly for the period of early communicative development, when standardized testing can be minimally informative. The purpose of the current study was to…
Descriptors: Genetic Disorders, Developmental Disabilities, Developmental Delays, Profiles
Monuteaux, Michael C.; Biederman, Joseph; Doyle, Alysa E.; Mick, Eric; Faraone, Stephen V. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Four hundred forty-four subjects aged 6-55 years were evaluated to examine the role of COMT and SLC6A4 genes in the risk for conduct disorder and its symptomatic subtypes in the context of attention deficit hyperactivity disorder. No significant association is found between these genes and the risk for conduct disorder.
Descriptors: Hyperactivity, Attention Deficit Disorders, Behavior Problems, Genetics
Goldman, S. E.; Malow, B. A.; Newman, K. D.; Roof, E.; Dykens, E. M. – Journal of Intellectual Disability Research, 2009
Background: Sleep disorders are common in individuals with neurodevelopmental disorders and may adversely affect daytime functioning. Children with Williams syndrome have been reported to have disturbed sleep; however, no studies have been performed to determine if these problems continue into adolescence and adulthood. Methods: This study…
Descriptors: Sleep, Young Adults, Adolescents, Genetic Disorders
Sund, Reijo; Pukkala, E.; Patja, K. – Journal of Intellectual Disability Research, 2009
Background: Fragile X syndrome is a common inheritable cause of intellectual disability (ID) and is characterised by a large number of CGG repeats at the gene "FMR1" located on the X-chromosome. It has been reported that this genetic mechanism may protect against malignant transformations. Methods: We extracted from the Finnish registry…
Descriptors: Incidence, Mental Retardation, Cancer, Foreign Countries
Anand, Vibha – ProQuest LLC, 2010
Biomedical research has produced vast amounts of new information in the last decade but has been slow to find its use in clinical applications. Data from disparate sources such as genetic studies and summary data from published literature have been amassed, but there is a significant gap, primarily due to a lack of normative methods, in combining…
Descriptors: Diseases, Genetics, Biomedicine, Organizations (Groups)
Diaz, Jose Luis – International Social Science Journal, 2010
Bioethics is concerned with the moral aspects of biology and medicine. The bioethical relevance of aggression and violence is clear, as very different moral and legal responsibilities may apply depending on whether aggression and violence are forms of behaviour that are innate or acquired, deliberate or automatic or not, or understandable and…
Descriptors: Child Development, Biology, Natural Sciences, Legal Responsibility
Mick, Eric; Todorov, Alexandre; Smalley, Susan; Hu, Xiaolan; Loo, Sandra; Todd, Richard D.; Biederman, Joseph; Byrne, Deirdre; Dechairo, Bryan; Guiney, Allan; McCracken, James; McGough, James; Nelson, Stanley F.; Reiersen, Angela M.; Wilens, Timothy E.; Wozniak, Janet; Neale, Benjamin M.; Faraone, Stephen V. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Genes likely play a substantial role in the etiology of attention-deficit/hyperactivity disorder (ADHD). However, the genetic architecture of the disorder is unknown, and prior genome-wide association studies (GWAS) have not identified a genome-wide significant association. We have conducted a third, independent, multisite GWAS of…
Descriptors: Evidence, Attention Deficit Hyperactivity Disorder, Quality Control, Genetics
Hall, Scott S.; Lightbody, Amy A.; Hirt, Melissa; Rezvani, Ava; Reiss, Allan L. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Many investigators now routinely classify children with fragile X syndrome (FXS) according to whether or not they also meet diagnostic criteria for autism. To determine whether this classification is appropriate, we examined the profiles of autistic behaviors shown by boys and girls with FXS. Method: Individuals with FXS, aged 5 to 25…
Descriptors: Genetic Disorders, Mental Retardation, Congenital Impairments, Autism
Fontaine, Nathalie M. G.; Rijsdijk, Fruhling V.; McCrory, Eamon J. P.; Viding, Essi – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To investigate the longitudinal development of callous-unemotional traits (CU) in middle childhood using developmental trajectory analyses in a large twin dataset and examine the degree to which genetic and environmental influences contributed to the CU trajectory-group membership in children. Method: The study included 9,462 youths…
Descriptors: Group Membership, Twins, Females, Early Adolescents
Antshel, Kevin M.; Shprintzen, Robert; Fremont, Wanda; Higgins, Anne Marie; Faraone, Stephen V.; Kates, Wendy R. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS). Method: A total of 70 youth with VCFS, 27 siblings of youth with VCFS, and 25 community controls were followed from childhood (mean age = 11.8 years) into mid-adolescence (mean age = 15.0 years). Psychological tests measuring intelligence, academic…
Descriptors: Children, Adolescents, Congenital Impairments, Genetic Disorders
Valkenburg, Abraham J.; van Dijk, Monique; de Klein, Annelies; van den Anker, Johannes N.; Tibboel, Dick – Developmental Disabilities Research Reviews, 2010
The primary focus of pain research in intellectually disabled individuals is still on pain assessment. Several observational pain assessment scales are available, each with its own characteristics, its own target group and its own validated use. Observational studies report differences in the treatment of intra- and postoperative pain of…
Descriptors: Pain, Down Syndrome, Mental Retardation, Outcomes of Treatment
Hogan, Alexandra M.; Virues-Ortega, Javier; Botti, Ana Baya; Bucks, Romola; Holloway, John W.; Rose-Zerilli, Matthew J.; Palmer, Lyle J.; Webster, Rebecca J.; Baldeweg, Torsten; Kirkham, Fenella J. – Developmental Science, 2010
Millions of people currently live at altitudes in excess of 2500 metres, where oxygen supply is limited, but very little is known about the development of brain and behavioural function under such hypoxic conditions. We describe the physiological, cognitive and behavioural profile of a large cohort of infants (6-12 months), children (6-10 years)…
Descriptors: Ethnicity, American Indians, Adolescents, Foreign Countries

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