Pilocytic astrocytomas are WHO grade I gliomas that occur predominantly in childhood. They share features of both astroglial and oligodendroglial lineages. These tumours affect preferentially the cerebellum (benign clinical course) and the optic pathway, especially the hypothalamo-chiasmatic region (poor prognosis). Understanding the molecular…

The neural bases of prosody during the production of literal and idiomatic interpretations of literally plausible idioms was investigated. Left- and right-hemisphere-damaged participants and normal controls produced literal and idiomatic versions of idioms ("He hit the books.") All groups modulated duration to distinguish the interpretations. LHD…

This is the second part of a review of the work of quantum physicists on the "hard part" of the problem of mind. After an introduction which sets the scene and a brief review of contemporary work on the neural correlates of consciousness (NCC) the work of four prominent modern investigators is examined: J.C. Eccles/Friedrich Beck; Henry Stapp;…

Strategy effects on word searching in the Japanese letter fluency test were investigated using the Near-infrared Spectroscopy (NIRS). Participants were given a Japanese letter fluency test and they were classified into two types of strategy users, based on analysis of their recorded verbal responses. One group, AIUEO-order strategy users, employed…

Dr. Jay Giedd says that the main alterations in the adolescent brain are the inverted U-shaped developmental trajectories with late childhood/early teen peaks for gray matter volume among others. Giedd adds that the adolescent brain is vulnerable to substances that artificially modulate dopamine levels since its reward system is in a state of flux.

Over the past 50 years the concept of attention deficit/hyperactivity disorder (ADHD) has developed from the notion of a specific form of brain dysfunction to that of a heterogeneous set of related behaviours. The great advances in genetics, neuroimaging and neuropsychiatry have made it one of the best understood forms of complex mental…

Background monitoring is a necessary prerequisite to detect unexpected changes in the environment, while being involved in a primary task. Here, we used fMRI to investigate the neural mechanisms that underlie adaptive goal-directed behavior in a cued task switching paradigm during real response conflict or, more generally, when expectations on the…

Is it advantageous to be strongly lateralized? The current study investigated this question by examining the relationship between visual field asymmetries for lexical tasks and reading performance in a sample of 200 young adults. Larger visual field asymmetries were associated with better reading performance, but this relationship was obtained…

This behavioral study aimed at assessing the effect of two variables on the degree of hemispheric specialization for language. One of them was the "grapho-phonemic translation (transformation)" (letter-sound mapping) and the other was the participants' "gender". The experiment was conducted with healthy volunteers. A divided visual field procedure…

Endogenous biological clocks are widespread regulators of behavior and physiology, allowing for a more efficient allocation of efforts and resources over the course of a day. The extent that different processes are regulated by circadian oscillators, however, is not fully understood. We investigated the role of the circadian clock on short-term…

Ample evidence suggests that activation of NMDA receptors (NMDAr) in the basolateral complex of the amygdala (BLA) is necessary for context fear conditioning. The present series of experiments examined whether this activation was still required when the to-be-shocked context had a history. We found that BLA infusion of the selective NMDAr…

During adolescence, cognitive abilities increase robustly. To search for possible related structural alterations of the cerebral cortex, we measured neuronal soma dimension (NSD = width times height), cortical thickness and neuronal densities in different types of neocortex in post-mortem brains of five 12-16 and five 17-24 year-olds (each 2F,…

Roberts Bartholow's 1874 experiment on Mary Rafferty is widely cited as the first demonstration, by direct application of stimulating electrodes, of the motor excitability of the human cerebral cortex. The many accounts of the experiment, however, leave certain questions and details unexamined or unresolved, especially about Bartholow's goals, the…

fMR-Adaptation, where a pair of identical stimuli elicits a smaller neural response than a pair of dissimilar stimuli has been extensively used to study object identification and classification as well as memory. Thus far this technique has found limited application in evaluating brain areas sensitive to meaning, language and control of language…

Changes in oscillatory brain activity have been related to perceptual and cognitive processes such as selective attention and memory matching. Here we examined brain oscillations, measured with electroencephalography (EEG), during a semantic speech processing task that required both lexically mediated memory matching and selective attention.…