What have librarians got to do with brain research? Much more than most librarians realize, says Betsy Diamant-Cohen, Children's Programming Specialist at the Enoch Pratt Free Library, Baltimore. Her original plan was to be a social worker, but it was suggested that she could be equally effective in improving lives as a librarian--while having a…

While motor dominance appears to drive limb selection for reaching movements at the midline and ipsilateral (dominant) side, this study examined the possible determinants associated with what drives the programming of movements in response to stimuli presented in contralateral space. Experiment 1 distinguished between object proximity and a…

What forms the basis of musical expressivity? The Swiss composer and music educator, Emile Jaques-Dalcroze, believed that bodily processes, rhythm, and physical motion were the basis of musical expressivity and music pedagogy. We can rephrase his emphasis on the synergy between bodily and musical processes into a question: How does the body…

Paraneoplastic cerebellar degeneration (PCD) is an autoimmune disease that can be associated with cancer of the breast, lung, and ovary. The clinical presentation of PCD commonly includes ataxia, visual disturbances, and dysarthria. The speech disturbances associated with PCD have not been well characterized, despite general acceptance that…

Leukoencephalopathy with vanishing white matter (VWM) is an autosomal recessive brain disorder, most often with a childhood onset. Magnetic resonance imaging and spectroscopy indicate that, with time, increasing amounts of cerebral white matter vanish and are replaced by fluid. Autopsy confirms white matter rarefaction and cystic degeneration. The…

In this paper studies of executive function in autism spectrum disorder are reviewed. Executive function is an umbrella term for functions such as planning, working memory, impulse control, inhibition, and shifting set, as well as for the initiation and monitoring of action. In this review, the focus will be on planning, inhibition, shifting set,…

Several lesion and imaging studies have suggested that the Wisconsin Card Sorting Test (WCST) is a measure of executive dysfunction. However, some studies have reported that this measure has poor anatomical specificity because patients with either frontal or non-frontal focal lesions exhibit similar performance. This study examined 25 frontal, 20…

Diagonistic dyspraxia is a clinical syndrome usually characterized by involuntary and conflicting behaviors between the hands following corpus callosum lesions. In the present study, we report the case of a patient who presents such symptoms, along with a series of complex abnormal behaviors, such as carrying out an action and subsequently doing…

Alcoholism is a major health problem afflicting people all over the world. Understanding the neural substrates of this addictive disorder may provide the basis for effective interventions. So-called ''executive processes'' play a role in cognitive functions like attention and working memory, and appear to be disrupted in alcoholism (Noel et al.,…

For the past several years it has been thought that cues, such as eye direction, can trigger reflexive shifts in attention because of their biological relevance and their specialized neural architecture. However, very recently, Ristic, Friesen, and Kingstone (2002) reported that other stimuli, such as arrows, trigger reflexive shifts in attention…

Aphasia is a total or partial loss of the ability to produce or understand language, usually caused by brain disease or injury. In this case study, the aphasic patient (BMW) has a profound impairment of oral production and a very moderate impairment in comprehension. Several years of informal observation lead to the current study that contrasts…

Broca's region in the dominant cerebral hemisphere is known to mediate the production of language but also contributes to comprehension. This region evolved only in humans and is constituted of Brodmann's areas 44 and 45 in the inferior frontal gyrus. There is, however, evidence that Broca's region overlaps, at least in part, with the ventral…

In this paper we examine a central issue in cognitive neuroscience: are there separate conceptual representations associated with different input modalities (e.g., Paivio, 1971, 1986; Warrington & Shallice, 1984) or do inputs from different modalities converge on to the same set of representations (e.g., Caramazza, Hillis, Rapp, & Romani, 1990;…

We present an acoustic study of segmental and prosodic properties of words produced by a female speaker of Chinese with left-hemisphere brain damage. We measured the location of the point vowels /a, e, @?, i, y, o, u/ and determined their separation in the vowel plane, and their perceptual distinctivity. Similarly, the acoustic properties of the…

Axonal degeneration contributes to the development of non-remitting neurological deficits and disability in multiple sclerosis, but the molecular mechanisms that underlie axonal loss in multiple sclerosis are not clearly understood. Studies of white matter axonal injury have demonstrated that voltage-gated sodium channels can provide a route for…