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Direct linkSelvarajah, Geeta; Selvarajah, Susila – Biochemistry and Molecular Biology Education, 2016
Students frequently expressed difficulty in understanding the molecular mechanisms involved in chromosomal recombination. Therefore, we explored alternative methods for presenting the two concepts of the double-strand break model: Holliday junction and heteroduplex formation, and Holliday junction resolution. In addition to a lecture and…
Descriptors: Genetics, Molecular Structure, Scientific Concepts, Models
Green Snyder, LeeAnne; D'Angelo, Debra; Chen, Qixuan; Bernier, Raphael; Goin-Kochel, Robin P.; Wallace, Arianne Stevens; Gerdts, Jennifer; Kanne, Stephen; Berry, Leandra; Blaskey, Lisa; Kuschner, Emily; Roberts, Timothy; Sherr, Elliot; Martin, Christa L.; Ledbetter, David H.; Spiro, John E.; Chung, Wendy K.; Hanson, Ellen – Journal of Autism and Developmental Disorders, 2016
The 16p11.2 duplication (BP4-BP5) is associated with Autism Spectrum Disorder (ASD), although significant heterogeneity exists. Quantitative ASD, behavioral and neuropsychological measures and DSM-IV diagnoses in child and adult carriers were compared with familial non-carrier controls, and to published results from deletion carriers. The 16p11.2…
Descriptors: Pervasive Developmental Disorders, Developmental Disabilities, Psychiatry, Statistical Analysis
Prevost, Luanna B.; Smith, Michelle K.; Knight, Jennifer K. – CBE - Life Sciences Education, 2016
Previous work has shown that students have persistent difficulties in understanding how central dogma processes can be affected by a stop codon mutation. To explore these difficulties, we modified two multiple-choice questions from the Genetics Concept Assessment into three open-ended questions that asked students to write about how a stop codon…
Descriptors: Science Instruction, Genetics, Scientific Concepts, Scoring
Thomas, Michael S. C.; Davis, Rachael; Karmiloff-Smith, Annette; Knowland, Victoria C. P.; Charman, Tony – Developmental Science, 2016
This article outlines the "over-pruning hypothesis" of autism. The hypothesis originates in a neurocomputational model of the regressive sub-type (Thomas, Knowland & Karmiloff-Smith, 2011a, 2011b). Here we develop a more general version of the over-pruning hypothesis to address heterogeneity in the timing of manifestation of ASD,…
Descriptors: Autism, Pervasive Developmental Disorders, Computer Simulation, Symptoms (Individual Disorders)
Patricia J. Friedrichsen; Troy D. Sadler; Kerri Graham; Pamela Brown – International Journal of Designs for Learning, 2016
In this design case, we describe our work to design and develop a socio-scientific issue (SSI) based unit of instruction for use in high school biology. Our team includes university based science educators, an experienced classroom teacher, and a microbiologist. The unit focuses on antibiotic resistant bacteria as a context for student exploration…
Descriptors: Science and Society, Secondary School Science, Science Instruction, Instructional Design
Gupta-Agarwal, Swati; Jarome, Timothy J.; Fernandez, Jordan; Lubin, Farah D. – Learning & Memory, 2014
It is well established that fear memory formation requires de novo gene transcription in the amygdala. We provide evidence that epigenetic mechanisms in the form of histone lysine methylation in the lateral amygdala (LA) are regulated by NMDA receptor (NMDAR) signaling and involved in gene transcription changes necessary for fear memory…
Descriptors: Memory, Genetics, Brain Hemisphere Functions, Neurological Organization
Bargmann, Bastiaan O. R.; Birnbaum, Kenneth D.; Brenner, Eric D. – Biochemistry and Molecular Biology Education, 2014
We present a lab that enables students to test the role of genes involved in the regulation of lateral roots growth in the model plant "Arabidopsis thaliana." Here, students design an experiment that follows the effects of the hormone auxin on the stimulation of genes involved in the formation of lateral root initials. These genes, known…
Descriptors: Science Instruction, College Science, Genetics, Science Laboratories
Giersch, Anne; Glaser, Bronwyn; Pasca, Catherine; Chabloz, Mélanie; Debbané, Martin; Eliez, Stephan – American Journal on Intellectual and Developmental Disabilities, 2014
Individuals with 22q11.2 deletion syndrome (22q11.2DS) are impaired at exploring visual information in space; however, not much is known about visual form discrimination in the syndrome. Thirty-five individuals with 22q11.2DS and 41 controls completed a form discrimination task with global forms made up of local elements. Affected individuals…
Descriptors: Genetic Disorders, Cognitive Ability, Visual Perception, Visual Discrimination
Ware, Elizabeth A.; Gelman, Susan A. – Cognitive Science, 2014
This set of seven experiments examines reasoning about the inheritance and acquisition of physical properties in preschoolers, undergraduates, and biology experts. Participants (N = 390) received adoption vignettes in which a baby animal was born to one parent but raised by a biologically unrelated parent, and they judged whether the offspring…
Descriptors: Vignettes, Adoption, Animals, Genetics
Jiménez-Aleixandre, María Pilar – Science & Education, 2014
In the last two decades science studies and science education research have shifted from an interest in products (of science or of learning), to an interest in processes and practices. The focus of this paper is on students' engagement in epistemic practices (Kelly in "Teaching scientific inquiry: Recommendations for research and…
Descriptors: Science Education, Educational Research, Science Process Skills, Epistemology
Sugarman, Michael A.; Jacobs, Dennis R.; Paulson, Daniel; Tomlinson, M. Michele; Lichtenberg, Peter A. – Journal of Intellectual & Developmental Disability, 2014
Background: The goal of the current study was to determine if the Dementia Rating Scale-2 (DRS-2) is an appropriate tool for evaluating cognitive abilities in adults with Prader-Willi syndrome (PWS). The DRS-2 is a screening measure previously utilised in low-functioning populations with and without dementia, including individuals with…
Descriptors: Genetic Disorders, Dementia, Rating Scales, Adults
Tosto, Maria G.; Hayiou-Thomas, Marianna E.; Harlaar, Nicole; Prom-Wormley, Elizabeth; Dale, Philip S.; Plomin, Robert – Developmental Psychology, 2017
This study examines the genetic and environmental etiology underlying the development of oral language and reading skills, and the relationship between them, over a long period of developmental time spanning middle childhood and adolescence. It focuses particularly on the differential relationship between language and two different aspects of…
Descriptors: Twins, Genetics, Reading Fluency, Structural Equation Models
Munn, Maureen; Knuth, Randy; Van Horne, Katie; Shouse, Andrew W.; Levias, Sheldon – CBE - Life Sciences Education, 2017
This study examines how two kinds of authentic research experiences related to smoking behavior--genotyping human DNA (wet lab) and using a database to test hypotheses about factors that affect smoking behavior (dry lab)--influence students' perceptions and understanding of scientific research and related science concepts. The study used pre and…
Descriptors: Science Laboratories, Smoking, Genetics, Hypothesis Testing
Selzam, Saskia; Dale, Philip S.; Wagner, Richard K.; DeFries, John C.; Cederlöf, Martin; O'Reilly, Paul F.; Krapohl, Eva; Plomin, Robert – Scientific Studies of Reading, 2017
It is now possible to create individual-specific genetic scores, called genome-wide polygenic scores (GPS). We used a GPS for years of education ("EduYears") to predict reading performance assessed at UK National Curriculum Key Stages 1 (age 7), 2 (age 12) and 3 (age 14) and on reading tests administered at ages 7 and 12 in a UK sample…
Descriptors: Genetics, Biological Sciences, Scores, Prediction
Stern, Florian; Kampourakis, Kostas – Studies in Science Education, 2017
Research in genetics and genomics is advancing at a fast pace, and thus keeping up with the most recent findings and conclusions can be very challenging. At the same time these recent findings and conclusions have made necessary a reconceptualization of genes and heredity, both in science and in science education, beyond the mostly gene-centred…
Descriptors: Genetics, Literacy, Science Instruction, Teaching Methods
