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Direct linkHartelius, Lena; Jonsson, Maria; Rickeberg, Anneli; Laakso, Katja – International Journal of Language & Communication Disorders, 2010
Background: As an effect of the cognitive, emotional and motor symptoms associated with Huntington's disease, communicative interaction is often dramatically changed. No study has previously included the subjective reports on this subject from individuals with Huntington's disease. Aims: To explore the qualitative aspects of how communication is…
Descriptors: Genetic Disorders, Neurological Impairments, Adults, Family (Sociological Unit)
Download full textShumate, Alice M.; Windsor, Aaron J. – Bioscene: Journal of College Biology Teaching, 2010
The increase in publications presenting molecular evolutionary analyses and the availability of comparative sequence data through resources such as NCBI's GenBank underscore the necessity of providing undergraduates with hands-on sequence analysis skills in an evolutionary context. This need is particularly acute given that students have been…
Descriptors: Evolution, Computer Software, Genetics, Laboratories
Hoffman, Ellen J.; State, Matthew W. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: This review considers the impact of chromosomal studies on the understanding of childhood neuropsychiatric syndromes, highlighting key discoveries, advances in technology, and new challenges faced by clinicians trying to interpret recent findings. Method: We review the literature on the genetics of child psychiatric disorders, including…
Descriptors: Attention Deficit Hyperactivity Disorder, Investigations, Schizophrenia, Emotional Disturbances
Wood, Alexis C.; Neale, Michael C. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To describe the utility of twin studies for attention-deficit/hyperactivity disorder (ADHD) research and demonstrate their potential for the identification of alternative phenotypes suitable for genomewide association, developmental risk assessment, treatment response, and intervention targets. Method: Brief descriptions of the classic…
Descriptors: Attention Deficit Hyperactivity Disorder, Research Tools, Structural Equation Models, Clinical Diagnosis
Transler, Catherine; Eilander, Ans; Mitchell, Siobhan; van de Meer, Nelly – Journal of Attention Disorders, 2010
Objectives: To review the impact of polyunsaturated fatty acids (PUFA) in reducing ADHD symptoms in children. Methods: Peer-reviewed experimental literature published from 1980 to Mai 2009 is consulted (Psychinfo, Medline, and resulting reference lists). Results: Placebo-controlled studies with ADHD or hyperactive children show no effects on…
Descriptors: Attention Deficit Hyperactivity Disorder, Attention Deficit Disorders, Neurology, Nutrition
Paloyelis, Yannis; Rijsdijk, Fruhling; Wood, Alexis C.; Asherson, Philip; Kuntsi, Jonna – Journal of Abnormal Child Psychology, 2010
Previous studies have documented the primarily genetic aetiology for the stronger phenotypic covariance between reading disability and ADHD inattention symptoms, compared to hyperactivity-impulsivity symptoms. In this study, we examined to what extent this covariation could be attributed to "generalist genes" shared with general cognitive ability…
Descriptors: Reading Difficulties, Conceptual Tempo, Structural Equation Models, Attention Deficit Hyperactivity Disorder
Liu, Xinmin; Akula, Nirmala; Skup, Martha; Brotman, Melissa A.; Leibenluft, Ellen; McMahon, Francis J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Functional magnetic resonance imaging is commonly used to characterize brain activity underlying a variety of psychiatric disorders. A previous functional magnetic resonance imaging study found that amygdala activation during a face-processing task differed between pediatric patients with bipolar disorder (BD) and healthy controls. We…
Descriptors: Quality Control, Adolescents, Patients, Genetics
Utari, Agustini; Chonchaiya, Weerasak; Rivera, Susan M.; Schneider, Andrea; Hagerman, Randi J.; Faradz, Sultana M. H.; Ethell, Iryna M.; Nguyen, Danh V. – American Journal on Intellectual and Developmental Disabilities, 2010
Minocycline can rescue the dendritic spine and synaptic structural abnormalities in the fragile X knock-out mouse. This is a review and preliminary survey to document side effects and potential outcome measures for minocycline use in the treatment of individuals with fragile X syndrome. We surveyed 50 patients with fragile X syndrome who received…
Descriptors: Behavior Disorders, Patients, Drug Therapy, Genetic Disorders
Leventer, Richard J.; Jansen, Anna; Pilz, Daniela T.; Stoodley, Neil; Marini, Carla; Dubeau, Francois; Malone, Jodie; Mitchell, L. Anne; Mandelstam, Simone; Scheffer, Ingrid E.; Berkovic, Samuel F.; Andermann, Frederick; Andermann, Eva; Guerrini, Renzo; Dobyns, William B. – Brain, 2010
Polymicrogyria is one of the most common malformations of cortical development and is associated with a variety of clinical sequelae including epilepsy, intellectual disability, motor dysfunction and speech disturbance. It has heterogeneous clinical manifestations and imaging patterns, yet large cohort data defining the clinical and imaging…
Descriptors: Age, Epilepsy, Mental Retardation, Seizures
Boutwell, Brian B.; Beaver, Kevin M. – Journal of Research in Crime and Delinquency, 2010
There is a vast line of literature showing that antisocial behaviors and personality traits are transmitted across generational lines. Given the ascendancy of Gottfredson and Hirschi's general theory of crime, it is somewhat surprising that no research has examined whether levels of self-control are passed from parent to child. The authors examine…
Descriptors: Personality Traits, Risk, Marriage, Antisocial Behavior
Ronald, Angelica; Happe, Francesca; Dworzynski, Katharina; Bolton, Patrick; Plomin, Robert – Child Development, 2010
Prenatal and neonatal events were reported by parents of 13,690 eighteen-month-old twins enrolled in the Twins Early Development Study, a representative community sample born in England and Wales. At ages 7-8, parents and teachers completed questionnaires on social and nonsocial autistic-like features and parents completed the Childhood Asperger…
Descriptors: Twins, Asperger Syndrome, Questionnaires, Foreign Countries
Uebel, Henrik; Albrecht, Bjorn; Asherson, Philip; Borger, Norbert A.; Butler, Louise; Chen, Wai; Christiansen, Hanna; Heise, Alexander; Kuntsi, Jonna; Schafer, Ulrike; Andreou, Penny; Manor, Iris; Marco, Rafaela; Miranda, Ana; Mulligan, Aisling; Oades, Robert D.; van der Meere, Jaap; Faraone, Stephen V.; Rothenberger, Aribert; Banaschewski, Tobias – Journal of Child Psychology and Psychiatry, 2010
Background: Attention-deficit hyperactivity disorder (ADHD) is one of the most common and highly heritable child psychiatric disorders. There is strong evidence that children with ADHD show slower and more variable responses in tasks such as Go/Nogo tapping aspects of executive functions like sustained attention and response control which may be…
Descriptors: Siblings, Attention Deficit Hyperactivity Disorder, Genetics, Cognitive Processes
Schmitz, Marcelo; Ludwig, Henrique; Rohde, Luis A. – Journal of Clinical Child and Adolescent Psychology, 2010
The objective of the current study was to evaluate a proposed restrictive inattentive type of Attention Deficit Hyperactivity Disorder (ADHD) by comparing clinical correlates among youths with ADHD inattentive type (ADHD-I) as a function of the number of hyperactivity symptoms presented (none vs. 3 or less) and controls (individuals without ADHD).…
Descriptors: Genetics, Attention Deficit Hyperactivity Disorder, Foreign Countries, Control Groups
Pierpont, Elizabeth I.; Weismer, Susan Ellis; Roberts, Amy E.; Tworog-Dube, Erica; Pierpont, Mary Ella; Mendelsohn, Nancy J.; Seidenberg, Mark S. – Journal of Speech, Language, and Hearing Research, 2010
Purpose: This study presents an analysis of language skills in individuals with Noonan syndrome (NS), an autosomal dominant genetic disorder. We investigated whether the language impairments affecting some individuals arise from deficits specifically within the linguistic system or whether they are associated with cognitive, perceptual, and motor…
Descriptors: Genetic Disorders, Congenital Impairments, Children, Adolescents
Ellington, Roni; Wachira, James; Nkwanta, Asamoah – CBE - Life Sciences Education, 2010
The focus of this Research Experience for Undergraduates (REU) project was on RNA secondary structure prediction by using a lattice walk approach. The lattice walk approach is a combinatorial and computational biology method used to enumerate possible secondary structures and predict RNA secondary structure from RNA sequences. The method uses…
Descriptors: Genetics, Prediction, Microbiology, Epilepsy
