Individual differences in cortical anatomy are readily observable, but their functional significance for behaviors such as reading is not well understood. Here, we report a case of an apparent compensated dyslexic who had attained high achievement in visuospatial mathematics. Data from a detailed background interview, psychometric testing, divided…

Background: Childhood onset schizophrenia (COS) is a rare but severe form of the adult onset disorder. While structural brain imaging studies show robust, widespread, and progressive gray matter loss in COS during adolescence, there have been no longitudinal studies of sufficient duration to examine comparability with the more common adult onset…

Background: Longitudinal pediatric neuroimaging studies have demonstrated increasing volumes of white matter and regionally-specific inverted U shaped developmental trajectories of gray matter volumes during childhood and adolescence. Studies of monozygotic and dyzygotic twins during this developmental period allow exploration of genetic and…

Background: Brain activation differences between 12 control and 12 attention deficit hyperactivity disorder (ADHD) children (9- to 12-year-olds) were examined on two cognitive tasks during functional magnetic resonance imaging (fMRI). Method: Visual selective attention was measured with the visual search of a conjunction target (red triangle) in a…

The amygdala appears necessary for enhanced long-term memory associated with emotionally arousing events. Recent brain imaging investigations support this view and indicate a sex-related hemispheric lateralization exists in the amygdala relationship to memory for emotional material. This study confirms and further explores this finding. Healthy…

Objective: To investigate the association between mesial temporal lobe morphology, ratios of prefrontal cortex to amygdala and hippocampus volumes, and psychiatric symptomatology in children and adolescents with velocardiofacial syndrome (VCFS). Method: Scores on behavioral rating scales and volumetric measures of the amygdala, hippocampus, and…

"Science Briefs" summarize the findings and implications of a recent study in basic science or clinical research. This Brief summarizes the findings and implications of "Moderate Fetal Alcohol Exposure Impairs the Neurogenic Response to an Enriched Environment in Adult Mice" (I. Y. Choi; A. M. Allan; and L. A. Cunningham). Observations of mice…

This article presents 3 studies that examine how students and experts employ mental rotation and a learned heuristic to solve chemistry tasks that involve spatial information. Results from Study 1 indicate that despite instruction in analytical strategies, students choose to employ mental rotation on canonical assessment tasks. In Study 2, experts…

When bisecting words in their middle, people reveal leftward bisection errors. This tendency might emerge from an attentional bias towards the beginning of the word. However, when longer meaningless letter strings are presented, people reveal a rightward bisection bias. To test the role of semantic information on leftward or rightward bisection…

Poor readers perform worse than their normal reading peers on a variety of speech perception tasks, which may be linked to their phonological processing abilities. The purpose of the study was to compare the brain activation patterns of normal and impaired readers on speech perception to better understand the phonological basis in reading…

Research investigating risk perception suggests that not only the quantitative parameters used in technical risk assessment (i.e., frequency and severity of harm) but also "qualitative" aspects such as the dread a hazard provokes or its controllability influence risk judgments. It remains to be elucidated, however, which neural mechanism underlie…

It is generally well known that linguistic perseveration is a common symptom in individuals with brain damage and that its manifestation may be at the phonological, syntactic and/or semantic levels. The influence of perseveratory behavior on a subject's response to test stimuli and in therapeutic process has triggered the interests of the speech…

I advance the hypothesis that the earliest phases of language acquisition--the developmental transition from an initial universal state of language processing to one that is language-specific--requires social interaction. Relating human language learning to a broader set of neurobiological cases of communicative development, I argue that the…

Early experience preserves and refines many capabilities that emerge prenatally. Here we describe another role that it plays--establishing the neural substrate for capabilities that emerge at a much later point in development. The evidence comes from sleeper effects: permanent deficits when early experience was absent in capabilities that normally…

In the adult human brain, the presence of a system matching the observation and the execution of actions is well established. This mechanism is thought to rely primarily on the contribution of so-called "mirror neurons", cells that are active when a specific gesture is executed as well as when it is seen or heard. Despite the wealth of evidence…