The authors present a neurological theory of how cognitive information and emotional information are integrated in the nucleus accumbens during effective decision making. They describe how the nucleus accumbens acts as a gateway to integrate cognitive information from the ventromedial prefrontal cortex and the hippocampus with emotional…

According to a recent theory, anterior cingulate cortex is sensitive to response conflict, the coactivation of mutually incompatible responses. The present research develops this theory to provide a new account of the error-related negativity (ERN), a scalp potential observed following errors. Connectionist simulations of response conflict in an…

The past two decades have yielded a recognition that intimate partner violence is ubiquitous. Although violence within relationships is bidirectional, there is acknowledgment that violence directed against women is more persistent and dangerous. Strategies for treatment of men have been largely unsuccessful, and studies of women-centered…

The transition to a market economy in Albania is a relatively long and complex process. It is characterized by the demolition of old structures and the establishment of new ones, often in parallel, until a new, completely different economic system emerges. During this difficult and innovative process, a myriad of interconnected problems have…

As many experimental psychologists and neuroscientists conceive of it, memory can be thought of as having a "home, even if still a hidden one, in the brain" (Tulving, 2002, p. 20). Such a way of conceiving of memory has led to valuable research (see Gazzaniga, 1995), but also to the neglect of important aspects of remembering as it takes place in…

This primer introduces a Special Section on brain imaging, which includes a commentary and 10 data papers presenting applications of brain imaging to questions on developmental psychopathology. This primer serves two purposes. First, the article summarizes the strength and weaknesses of various brain-imaging techniques typically employed in…

In white matter disorders such as leukodystrophies (LD), periventricular leucomalacia (PVL), or multiple sclerosis (MS), the hypomyelination or the remyelination failure by oligodendrocyte progenitor cells involves errors in the sequence of events that normally occur during development when progenitors proliferate, migrate through the white…

Gene therapy is unarguably the definitive way to treat, and possibly cure, genetic diseases. A straightforward concept in theory, in practice it has proven difficult to realize, even when directed to easily accessed somatic cell systems. Gene therapy for diseases in which the central nervous system (CNS) is the target organ presents even greater…

Schreuder and Baayen (Schreuder. R., & Baayen, R. H. (1997). How complex simplex words can be. "Journal of Memory and Language" 37, 118-139) report that lexical decision times to nouns are not sensitive to the cumulative frequency of the noun's morphological derivatives in its ''morphological family'', even though such a cumulative frequency…

Using both the lesion method and functional imaging (positron emission tomography) in large cohorts of subjects investigated with the same experimental tasks, we tested the following hypotheses: (A) that the retrieval of words which denote concrete entities belonging to distinct conceptual categories depends upon partially segregated regions in…

This study investigated the ability to describe and categorize common objects following brain injury. Thirteen subjects with moderate to severe traumatic brain injury (TBI) and 13 noninjured controls participated in this project. The project consisted of 3 parts: 1. A spontaneous condition, 2. A training session, and 3. An application condition.…

The primary objective in this paper is to present a framework to understand the structure of consciousness. We argue that consciousness has been difficult to define because there are different kinds of consciousness, hierarchically organized, which need to be differentiated. Our framework is based on evidence from adult focal lesion research. The…

Development of affective decision-making was studied in 48 children at two ages (3 and 4 years) using a simplified version of the Iowa Gambling Task (Bechara, Damasio, Damasio, & Anderson, 1994). On each of 50 trials, children chose from 1 of 2 decks of cards that, when turned, displayed happy and sad faces, corresponding to rewards (candies) won…

Through the use of several tests of cognition we have documented sex differences in young children, adolescents, and adults on tasks that rely on the integrity of the orbital prefrontal cortex. In children under three years of age, males performed with significantly fewer errors than did females on tests of object reversals. No significant sex…

Two experiments are reported that examine the possibility that exercise selectively influences different types of cognition. To our knowledge, these experiments represent the first attempt to study higher-cognitive processes during exercise. Theoretical thinking was guided by the transient hypofrontality hypothesis. In both experiments, athletes…